Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/TTC8/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "42", "attributes": { "gene_relationship": [ "Affecting the same tissue", "Colocalization", "Directly interacting" ], "protein_interactions": [ "(CCDC28B, TTC8)" ], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:47.071857" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI059" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/42/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/42/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CCDC28B" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/42/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/42/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/42/?format=api" } }, { "type": "GeneCombination", "id": "104", "attributes": { "gene_relationship": [ "Directly interacting", "Same protein complex", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(BBS1, TTC8)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:49.947289" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI140" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/104/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/104/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS1" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/104/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/104/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/104/?format=api" } }, { "type": "GeneCombination", "id": "107", "attributes": { "gene_relationship": [ "Directly interacting", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway", "Monogenic experiments only" ], "protein_interactions": [ "(ARL6, TTC8)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:50.085539" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI145" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/107/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/107/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ARL6" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/107/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/107/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/107/?format=api" } }, { "type": "GeneCombination", "id": "108", "attributes": { "gene_relationship": [ "Directly interacting", "Same protein complex", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(BBS7, TTC8)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:50.110675" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI146" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/108/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/108/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS7" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/108/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/108/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/108/?format=api" } }, { "type": "GeneCombination", "id": "214", "attributes": { "gene_relationship": [ "Directly interacting", "Same protein complex", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(BBS2, BBS4)", "(BBS2, TTC8)", "(BBS4, TTC8)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:55.599924" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI325" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/214/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/214/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "BBS4" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/214/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/214/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/214/?format=api" } }, { "type": "GeneCombination", "id": "427", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:08.373498" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI623" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/427/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/427/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS10" }, { "type": "Gene", "id": "NPHP1" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/427/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/427/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/427/?format=api" } }, { "type": "GeneCombination", "id": "1175", "attributes": { "gene_relationship": [], "protein_interactions": [], "common_pathways": [ "Organelle biogenesis and maintenance", "Cilium Assembly" ], "genecomb_metascore": 2, "lastmodified": "2024-02-29T15:02:21.807624" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1661" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1175/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1175/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "NPHP4" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1175/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1175/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1175/?format=api" } }, { "type": "GeneCombination", "id": "834", "attributes": { "gene_relationship": [ "Same protein complex", "Directly interacting", "Colocalization", "Same pathway", "Similar function", "Relevant pathways for phenotype" ], "protein_interactions": [ "(CEP290, BBS4)", "(CEP290, BBS1)", "(CEP290, TTC8)", "(BBS4, BBS1)", "(BBS4, TTC8)", "(BBS1, TTC8)" ], "common_pathways": [ "Organelle biogenesis and maintenance", "Cilium Assembly" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T14:46:41.795324" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1146" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/834/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/834/combinations/?format=api" } }, "genes": { "meta": { "count": 5 }, "data": [ { "type": "Gene", "id": "BBS1" }, { "type": "Gene", "id": "BBS4" }, { "type": "Gene", "id": "CEP290" }, { "type": "Gene", "id": "MKS1" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/834/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/834/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/834/?format=api" } } ] }