Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/TSC2/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "326", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:02.561058" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI475" }, { "type": "Combination", "id": "OLI484" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/326/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/326/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "HOXA1" }, { "type": "Gene", "id": "TSC2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/326/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/326/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/326/?format=api" } }, { "type": "GeneCombination", "id": "331", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:02.703317" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI480" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/331/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/331/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CACNA1C" }, { "type": "Gene", "id": "TSC2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/331/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/331/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/331/?format=api" } }, { "type": "GeneCombination", "id": "334", "attributes": { "gene_relationship": [ "Involved in the same disease", "Directly interacting", "Same pathway" ], "protein_interactions": [ "(TSC1, TSC2)" ], "common_pathways": [ "Gene expression (Transcription)", "Macroautophagy", "Generic Transcription Pathway", "AMPK signaling pathway", "Autophagy", "Autophagy - animal", "Choline metabolism in cancer", "Inhibition of TSC complex formation by PKB", "RNA Polymerase II Transcription", "TBC/RABGAPs", "Insulin signaling pathway", "Herpes simplex virus 1 infection", "Transcriptional Regulation by TP53", "MTOR signalling", "Membrane Trafficking", "Longevity regulating pathway", "Vesicle-mediated transport", "Phospholipase D signaling pathway", "Rab regulation of trafficking", "TP53 Regulates Metabolic Genes", "mTOR signaling pathway", "Human cytomegalovirus infection", "Cellular senescence", "Human papillomavirus infection", "PI3K-Akt signaling pathway", "Thermogenesis", "Signal Transduction" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:02.838704" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI485" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/334/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/334/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "TSC1" }, { "type": "Gene", "id": "TSC2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/334/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/334/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/334/?format=api" } }, { "type": "GeneCombination", "id": "344", "attributes": { "gene_relationship": [ "Involved in the same disease", "Directly interacting" ], "protein_interactions": [ "(TSC2, UBE3A)" ], "common_pathways": [ "Human papillomavirus infection" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:03.152517" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI496" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/344/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/344/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "TSC2" }, { "type": "Gene", "id": "UBE3A" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/344/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/344/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/344/?format=api" } } ] }