Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/PKD1/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "215",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Directly interacting",
                    "Same pathway"
                ],
                "protein_interactions": [
                    "(PKD1, PKD2)"
                ],
                "common_pathways": [
                    "Cilium Assembly",
                    "Cargo trafficking to the periciliary membrane"
                ],
                "genecomb_metascore": 2,
                "lastmodified": "2021-10-18T11:00:55.642031"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 3
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI326"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI327"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI1705"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/215/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/215/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "PKD1"
                        },
                        {
                            "type": "Gene",
                            "id": "PKD2"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/215/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/215/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/215/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "720",
            "attributes": {
                "gene_relationship": [
                    "Same organelle",
                    "Involved in the same disease",
                    "Same organelle",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 3,
                "lastmodified": "2022-08-04T14:15:01.431002"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI963"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/720/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/720/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "PKD1"
                        },
                        {
                            "type": "Gene",
                            "id": "PKHD1"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/720/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/720/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/720/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1255",
            "attributes": {
                "gene_relationship": [
                    "Monogenic experiments only"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 0,
                "lastmodified": "2024-02-29T15:02:23.486047"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1748"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1255/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1255/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 4
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "PKD1"
                        },
                        {
                            "type": "Gene",
                            "id": "POR"
                        },
                        {
                            "type": "Gene",
                            "id": "SOX9"
                        },
                        {
                            "type": "Gene",
                            "id": "SRCAP"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1255/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1255/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1255/?format=api"
            }
        }
    ]
}