Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/MKKS/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "47", "attributes": { "gene_relationship": [ "Directly interacting", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Monogenic experiments only", "Same pathway" ], "protein_interactions": [ "(BBS2, MKKS)" ], "common_pathways": [ "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:47.353260" }, "relationships": { "combination_set": { "meta": { "count": 6 }, "data": [ { "type": "Combination", "id": "OLI067" }, { "type": "Combination", "id": "OLI170" }, { "type": "Combination", "id": "OLI171" }, { "type": "Combination", "id": "OLI225" }, { "type": "Combination", "id": "OLI226" }, { "type": "Combination", "id": "OLI224" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/47/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/47/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "MKKS" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/47/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/47/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/47/?format=api" } }, { "type": "GeneCombination", "id": "61", "attributes": { "gene_relationship": [ "Involved in the same disease", "Similar function", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:00:47.966598" }, "relationships": { "combination_set": { "meta": { "count": 6 }, "data": [ { "type": "Combination", "id": "OLI085" }, { "type": "Combination", "id": "OLI143" }, { "type": "Combination", "id": "OLI175" }, { "type": "Combination", "id": "OLI177" }, { "type": "Combination", "id": "OLI084" }, { "type": "Combination", "id": "OLI1662" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/61/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/61/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS10" }, { "type": "Gene", "id": "MKKS" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/61/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/61/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/61/?format=api" } }, { "type": "GeneCombination", "id": "63", "attributes": { "gene_relationship": [ "Involved in the same disease", "Similar function", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(BBS12, MKKS)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:48.091017" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI087" }, { "type": "Combination", "id": "OLI1131" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/63/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/63/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS12" }, { "type": "Gene", "id": "BBS9" }, { "type": "Gene", "id": "MKKS" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/63/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/63/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/63/?format=api" } }, { "type": "GeneCombination", "id": "420", "attributes": { "gene_relationship": [ "Directly interacting", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(BBS2, BBS4)", "(BBS2, MKKS)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:01:08.022498" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI614" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/420/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/420/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "BBS4" }, { "type": "Gene", "id": "MKKS" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/420/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/420/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/420/?format=api" } }, { "type": "GeneCombination", "id": "45", "attributes": { "gene_relationship": [ "Colocalization", "Same pathway", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "BBSome-mediated cargo-targeting to cilium", "Cilium Assembly", "Organelle biogenesis and maintenance", "Cargo trafficking to the periciliary membrane" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T14:32:39.692747" }, "relationships": { "combination_set": { "meta": { "count": 5 }, "data": [ { "type": "Combination", "id": "OLI063" }, { "type": "Combination", "id": "OLI066" }, { "type": "Combination", "id": "OLI1436" }, { "type": "Combination", "id": "OLI1437" }, { "type": "Combination", "id": "OLI1435" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/45/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/45/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS1" }, { "type": "Gene", "id": "MKKS" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/45/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/45/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/45/?format=api" } }, { "type": "GeneCombination", "id": "1018", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "Organelle biogenesis and maintenance", "Cilium Assembly" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:27.538323" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1449" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1018/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1018/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "IFT172" }, { "type": "Gene", "id": "MKKS" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1018/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1018/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1018/?format=api" } }, { "type": "GeneCombination", "id": "1019", "attributes": { "gene_relationship": [ "Colocalization", "Indirectly interacting", "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2024-03-01T14:21:10.220280" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1450" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1019/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1019/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "MKKS" }, { "type": "Gene", "id": "PDE6B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1019/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1019/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1019/?format=api" } }, { "type": "GeneCombination", "id": "1017", "attributes": { "gene_relationship": [ "Colocalization", "Same pathway", "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [ "BBSome-mediated cargo-targeting to cilium", "Cilium Assembly", "Organelle biogenesis and maintenance", "Cargo trafficking to the periciliary membrane" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T14:21:20.327935" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1448" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1017/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1017/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS5" }, { "type": "Gene", "id": "MKKS" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1017/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1017/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1017/?format=api" } }, { "type": "GeneCombination", "id": "1172", "attributes": { "gene_relationship": [], "protein_interactions": [], "common_pathways": [ "Organelle biogenesis and maintenance", "Cilium Assembly" ], "genecomb_metascore": 2, "lastmodified": "2024-02-29T15:02:21.763057" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1658" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1172/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1172/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "MKKS" }, { "type": "Gene", "id": "NPHP4" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1172/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1172/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1172/?format=api" } } ] }