Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/BRCA1/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "511",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [
                    "PI3K-Akt signaling pathway",
                    "Signal Transduction"
                ],
                "genecomb_metascore": 0,
                "lastmodified": "2021-10-18T11:01:12.173919"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI722"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/511/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/511/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 4
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "BRCA1"
                        },
                        {
                            "type": "Gene",
                            "id": "NOS3"
                        },
                        {
                            "type": "Gene",
                            "id": "SCRIB"
                        },
                        {
                            "type": "Gene",
                            "id": "ZIC3"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/511/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/511/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/511/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "537",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 1,
                "lastmodified": "2021-10-18T11:01:14.389919"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI748"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/537/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/537/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 4
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "BRCA1"
                        },
                        {
                            "type": "Gene",
                            "id": "DLC1"
                        },
                        {
                            "type": "Gene",
                            "id": "SALL2"
                        },
                        {
                            "type": "Gene",
                            "id": "TMEM231"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/537/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/537/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/537/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1209",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease"
                ],
                "protein_interactions": [],
                "common_pathways": [
                    "Disease"
                ],
                "genecomb_metascore": 1,
                "lastmodified": "2024-02-29T15:02:22.554171"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1696"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1209/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1209/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "BRCA1"
                        },
                        {
                            "type": "Gene",
                            "id": "RNF43"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1209/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1209/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1209/?format=api"
            }
        }
    ]
}