Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/IDUA/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "1194",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 1,
                "lastmodified": "2024-02-29T15:02:22.214725"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1681"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1194/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1194/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 4
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "IDUA"
                        },
                        {
                            "type": "Gene",
                            "id": "INPPL1"
                        },
                        {
                            "type": "Gene",
                            "id": "ITGB4"
                        },
                        {
                            "type": "Gene",
                            "id": "ZEB1"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1194/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1194/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1194/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1197",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Relevant pathways for phenotype",
                    "Same pathway"
                ],
                "protein_interactions": [],
                "common_pathways": [
                    "Metabolic pathways",
                    "Metabolism"
                ],
                "genecomb_metascore": 2,
                "lastmodified": "2024-02-29T15:02:22.289652"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1684"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1197/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1197/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "IDUA"
                        },
                        {
                            "type": "Gene",
                            "id": "INPPL1"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1197/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1197/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1197/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1200",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 1,
                "lastmodified": "2024-02-29T15:02:22.342800"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1687"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1200/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1200/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "APEX1"
                        },
                        {
                            "type": "Gene",
                            "id": "IDUA"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1200/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1200/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1200/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1208",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 1,
                "lastmodified": "2024-02-29T15:02:22.533487"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1695"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1208/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1208/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 3
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "IDUA"
                        },
                        {
                            "type": "Gene",
                            "id": "LOXL1"
                        },
                        {
                            "type": "Gene",
                            "id": "ZNF469"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1208/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1208/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1208/?format=api"
            }
        }
    ]
}