Details for GeneCombination 380

2 genes linked to Gene Combination 380 PTPN11; SOS1
GENES RELATIONSHIP Directly interacting;Same pathway;Relevant pathways for phenotype
PROTEIN INTERACTIONS (PTPN11, SOS1)
COMMON PATHWAYS MAPK family signaling cascades;Downstream signaling of activated FGFR3;Signaling by FLT3 ITD and TKD mutants;signaling and aggregation;Proteoglycans in cancer;Chronic myeloid leukemia;Downstream signaling of activated FGFR4;Axon guidance;Hemostasis;Signaling by Receptor Tyrosine Kinases;Signaling by FGFR;Insulin receptor signalling cascade;FRS-mediated FGFR1 signaling;IRS-related events triggered by IGF1R;Cell surface interactions at the vascular wall;Ras signaling pathway;Downstream signaling of activated FGFR1;Signaling by PDGF;Signaling by EGFR;Interleukin-3;RET signaling;JAK-STAT signaling pathway;IGF1R signaling cascade;Signaling by FGFR2;Interleukin-5 and GM-CSF signaling;Developmental Biology;Renal cell carcinoma;Downstream signal transduction;Signaling by NTRK2 (TRKB);Signaling by SCF-KIT;Platelet activation;MAPK1/MAPK3 signaling;Activated NTRK2 signals through FRS2 and FRS3;Nervous system development;Signaling by FGFR3;Natural killer cell mediated cytotoxicity;Immune System;Signaling by FGFR1;Phospholipase D signaling pathway;Adaptive Immune System;Neurotrophin signaling pathway;FRS-mediated FGFR3 signaling;Cytokine Signaling in Immune system;Innate Immune System;FRS-mediated FGFR4 signaling;FLT3 signaling in disease;Signaling by Interleukins;Disease;Signaling by MET;Signaling by FGFR4;Tie2 Signaling;Downstream signaling of activated FGFR2;Diseases of signal transduction by growth factor receptors and second messengers;FLT3 Signaling;Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);Signaling by Insulin receptor;IRS-mediated signalling;FRS-mediated FGFR2 signaling;Signal Transduction;Signaling by NTRKs
GENEmeta 2
1 combination linked to Gene Combination 380 OLI568

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