| GENE NAME | TP53 |
| CHROMOSOME | 17 |
| ENSEMBL ID | ENSG00000141510 |
| ENTREZ ID | 7157 |
| UNIPROT ACCESSION NUMBER | P04637 |
| GO MOLECULAR FUNCTION | protease binding; DNA-binding transcription activator activity; enzyme binding; DNA-binding transcription activator activity, RNA polymerase II-specific; copper ion binding; histone deacetylase binding; cis-regulatory region sequence-specific DNA binding; ATP-dependent DNA/DNA annealing activity; histone acetyltransferase binding; protein heterodimerization activity; receptor tyrosine kinase binding; protein phosphatase 2A binding; protein binding; mRNA 3'-UTR binding; identical protein binding; core promoter sequence-specific DNA binding; disordered domain specific binding; chromatin binding; RNA polymerase II-specific DNA-binding transcription factor binding; histone deacetylase regulator activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; TFIID-class transcription factor complex binding; protein kinase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding; p53 binding; DNA binding; ubiquitin protein ligase binding; chaperone binding; promoter-specific chromatin binding; DNA-binding transcription factor activity; protein self-association; protein phosphatase binding; general transcription initiation factor binding; protein N-terminus binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding; zinc ion binding |
| ESSENTIAL IN MOUSE | Essential |
| PATHWAYS | hsa04310; hsa05016; hsa04137; hsa05219; hsa05205; R-HSA-109606; R-HSA-6811555; R-HSA-74160; hsa05213; hsa05223; hsa05214; R-HSA-5693532; R-HSA-8853884; R-HSA-1280215; R-HSA-453274; hsa05202; hsa04211; R-HSA-69560; hsa05224; R-HSA-6804754; R-HSA-6806003; hsa05212; hsa04151; R-HSA-6804760; hsa05012; hsa05203; R-HSA-349425; hsa05215; hsa05200; hsa04722; hsa05162; hsa05210; R-HSA-449147; hsa04218; R-HSA-8878159; hsa05166; R-HSA-9006925; hsa04210; R-HSA-5688426; hsa05218; hsa05169; hsa05161; R-HSA-6804759; hsa05230; R-HSA-5628897; R-HSA-8852276; hsa05220; R-HSA-69473; hsa05166; hsa04218; hsa05210; hsa05162; R-HSA-983231; hsa05200; hsa04722; hsa05215; R-HSA-8953897; hsa05203; R-HSA-1912408; R-HSA-5357801; R-HSA-6796648; hsa05220; R-HSA-69563; hsa05230; hsa05161; hsa05218; R-HSA-69541; hsa05169; R-HSA-6804756; R-HSA-73894; hsa04210; R-HSA-8943724; hsa05214; R-HSA-6804758; hsa05213; hsa05223; R-HSA-212436; hsa05205; hsa05219; hsa04137; hsa04310; hsa05016; R-HSA-109581; R-HSA-6785807; R-HSA-390471; R-HSA-6804115; R-HSA-73857; hsa05012; hsa05212; hsa04151; R-HSA-391251; hsa05224; hsa05202; hsa04211; R-HSA-168256; R-HSA-390466; R-HSA-2559583; hsa05014; hsa05160; R-HSA-111448; R-HSA-5689880; R-HSA-2990846; R-HSA-6803205; R-HSA-3700989; R-HSA-69481; R-HSA-69275; hsa05216; hsa05165; hsa04010; hsa05418; hsa05168; hsa05226; R-HSA-2559586; R-HSA-157118; hsa01524; hsa05206; R-HSA-1912422; R-HSA-6804757; R-HSA-69615; R-HSA-2559585; R-HSA-2559580; hsa05222; hsa04071; hsa05131; R-HSA-139915; R-HSA-3108232; R-HSA-6791312; hsa04115; R-HSA-6807070; R-HSA-6803204; hsa01522; R-HSA-5693606; R-HSA-6803207; hsa05163; R-HSA-1257604; R-HSA-3232118; hsa04919; R-HSA-69620; hsa04110; hsa05217; R-HSA-2559584; R-HSA-6804114; hsa04216; hsa05225; R-HSA-6803211; R-HSA-69278; hsa05167; R-HSA-6804116; hsa05163; hsa01522; R-HSA-69895; hsa04115; hsa04071; hsa05131; R-HSA-2262752; hsa05222; R-HSA-5633008; R-HSA-114452; R-HSA-162582; hsa05167; hsa04216; hsa05225; R-HSA-109582; R-HSA-8941855; hsa05217; hsa04110; hsa04919; hsa05168; hsa05216; R-HSA-5633007; R-HSA-5689896; hsa04010; hsa05418; hsa05165; R-HSA-1640170; R-HSA-597592; hsa05160; hsa05014; R-HSA-69580; R-HSA-392499; hsa01524; R-HSA-5693565; hsa05206; hsa05226 |
| 2 combinations linked to TP53 | OLI1054; OLI755 |
| 2 variants linked to TP53 | TP53:c.850A>T, p.Thr284Ser; TP53:c.475G>A, p.Ala159Thr |
| 2 diseases linked to TP53 | Isolated anencephaly; Primary ovarian failure |