GENE NAME | ROR2 |
CHROMOSOME | 9 |
ENSEMBL ID | None |
ENTREZ ID | ENSG00000169071 |
UNIPROT ACCESSION NUMBER | Q01974 |
GO MOLECULAR FUNCTION | ['Wnt-protein binding', 'mitogen-activated protein kinase kinase kinase binding', 'ATP binding', 'frizzled binding', 'protein binding', 'metal ion binding', 'coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity'] |
ESSENTIAL IN MOUSE | Essential |
PATHWAYS | hsa04310; R-HSA-162582; R-HSA-195721; R-HSA-3858494; R-HSA-4086400; R-HSA-5140745 |
5 combinations linked to ROR2 | OLI752; OLI1563; OLI1570; OLI702; OLI754 |
5 variants linked to ROR2 | ROR2:c.1624G>A, p.Val542Met; ROR2:c.2285C>T, p.Ser762Leu; ROR2:c.2080T>C, p.Cys694Arg; ROR2:c.332T>A, p.Ile111Asn; ROR2:c.1583G>A, p.Arg528Gln |
2 diseases linked to ROR2 | Isolated anencephaly; Syndrome with 46,XY disorder of sex development |