Details for Gene POLD1

GENE NAME POLD1
CHROMOSOME 19
ENSEMBL ID None
ENTREZ ID ENSG00000062822
UNIPROT ACCESSION NUMBER P28340
GO MOLECULAR FUNCTION ['chromatin binding', '4 iron, 4 sulfur cluster binding', 'enzyme binding', 'damaged DNA binding', 'DNA-directed DNA polymerase activity', 'DNA binding', "3'-5'-exodeoxyribonuclease activity", 'nucleotide binding', 'protein binding', 'metal ion binding']
ESSENTIAL IN MOUSE Essential
PATHWAYS hsa03030; hsa03410; hsa03420; hsa03430; hsa03440; hsa03030; hsa03410; hsa03420; hsa03430; hsa03440; R-HSA-110313; R-HSA-110314; R-HSA-110373; R-HSA-1430728; R-HSA-157579; R-HSA-1640170; R-HSA-174411; R-HSA-174414; R-HSA-174417; R-HSA-174437; R-HSA-180786; R-HSA-2564830; R-HSA-5358508; R-HSA-5358565; R-HSA-5358606; R-HSA-5651801; R-HSA-5656169; R-HSA-5685942; R-HSA-5693532; R-HSA-5693538; R-HSA-5693567; R-HSA-5696397; R-HSA-5696398; R-HSA-5696399; R-HSA-5696400; R-HSA-6781827; R-HSA-6782135; R-HSA-6782210; R-HSA-69091; R-HSA-69109; R-HSA-69166; R-HSA-69183; R-HSA-69186; R-HSA-69190; R-HSA-69239; R-HSA-69242; R-HSA-69278; R-HSA-69306; R-HSA-73884; R-HSA-73886; R-HSA-73893; R-HSA-73894; R-HSA-73933
1 combination linked to POLD1 OLI1457
1 variant linked to POLD1 POLD1:c.946G>A, p.Asp316Asn
1 disease linked to POLD1 Colorectal cancer
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