Details for Gene PIK3R1

GENE NAME PIK3R1
CHROMOSOME 5
ENSEMBL ID None
ENTREZ ID ENSG00000145675
UNIPROT ACCESSION NUMBER P27986
GO MOLECULAR FUNCTION ['phosphatidylinositol 3-kinase binding', 'insulin receptor binding', 'insulin binding', 'neurotrophin TRKA receptor binding', 'insulin-like growth factor receptor binding', 'phosphatidylinositol 3-kinase regulator activity', 'phosphotyrosine residue binding', 'ErbB-3 class receptor binding', 'protein heterodimerization activity', 'protein binding', 'protein phosphatase binding', 'transmembrane receptor protein tyrosine kinase adaptor activity', '1-phosphatidylinositol-3-kinase regulator activity', 'phosphatidylinositol 3-kinase regulatory subunit binding', 'insulin receptor substrate binding']
ESSENTIAL IN MOUSE Essential
PATHWAYS hsa01521; hsa01522; hsa01524; hsa04012; hsa04014; hsa04015; hsa04024; hsa04062; hsa04066; hsa04068; hsa04070; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04211; hsa04213; hsa04218; hsa04360; hsa04370; hsa04380; hsa04510; hsa04550; hsa04611; hsa04613; hsa04620; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04670; hsa04722; hsa04725; hsa04750; hsa04810; hsa04910; hsa04914; hsa04915; hsa04917; hsa04919; hsa04923; hsa04926; hsa04929; hsa04930; hsa04931; hsa04932; hsa04933; hsa04935; hsa04960; hsa04973; hsa05010; hsa05017; hsa05020; hsa05100; hsa05131; hsa05135; hsa05142; hsa05146; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05168; hsa05169; hsa05170; hsa05171; hsa05200; hsa05203; hsa05205; hsa05206; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231; hsa05235; hsa05418; hsa01521; hsa01522; hsa01524; hsa04012; hsa04014; hsa04015; hsa04024; hsa04062; hsa04066; hsa04068; hsa04070; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04211; hsa04213; hsa04218; hsa04360; hsa04370; hsa04380; hsa04510; hsa04550; hsa04611; hsa04613; hsa04620; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04670; hsa04722; hsa04725; hsa04750; hsa04810; hsa04910; hsa04914; hsa04915; hsa04917; hsa04919; hsa04923; hsa04926; hsa04929; hsa04930; hsa04931; hsa04932; hsa04933; hsa04935; hsa04960; hsa04973; hsa05010; hsa05017; hsa05020; hsa05100; hsa05131; hsa05135; hsa05142; hsa05146; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05168; hsa05169; hsa05170; hsa05171; hsa05200; hsa05203; hsa05205; hsa05206; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231; hsa05235; hsa05418; R-HSA-109582; R-HSA-109704; R-HSA-112399; R-HSA-114604; R-HSA-1226099; R-HSA-1227986; R-HSA-1227990; R-HSA-1236382; R-HSA-1236394; R-HSA-1250342; R-HSA-1257604; R-HSA-1266695; R-HSA-1266738; R-HSA-1280215; R-HSA-1280218; R-HSA-1430728; R-HSA-1433557; R-HSA-1483255; R-HSA-1483257; R-HSA-1500931; R-HSA-162582; R-HSA-1643685; R-HSA-1643713; R-HSA-1660499; R-HSA-166520; R-HSA-168249; R-HSA-168256; R-HSA-177929; R-HSA-180292; R-HSA-1839117; R-HSA-1839124; R-HSA-186763; R-HSA-186797; R-HSA-187037; R-HSA-190236; R-HSA-194138; R-HSA-1963642; R-HSA-198203; R-HSA-199418; R-HSA-202403; R-HSA-202424; R-HSA-202733; R-HSA-2029480; R-HSA-2029485; R-HSA-210993; R-HSA-2172127; R-HSA-2219528; R-HSA-2219530; R-HSA-2404192; R-HSA-2424491; R-HSA-2428924; R-HSA-2428928; R-HSA-2454202; R-HSA-2730905; R-HSA-372790; R-HSA-373753; R-HSA-388396; R-HSA-388841; R-HSA-389356; R-HSA-389357; R-HSA-416476; R-HSA-422475; R-HSA-430116; R-HSA-4420097; R-HSA-449147; R-HSA-451927; R-HSA-512988; R-HSA-556833; R-HSA-5637810; R-HSA-5637812; R-HSA-5637815; R-HSA-5654687; R-HSA-5654689; R-HSA-5654695; R-HSA-5654696; R-HSA-5654708; R-HSA-5654710; R-HSA-5654716; R-HSA-5654720; R-HSA-5654736; R-HSA-5654738; R-HSA-5654741; R-HSA-5654743; R-HSA-5655253; R-HSA-5655291; R-HSA-5655302; R-HSA-5655332; R-HSA-5663202; R-HSA-5673001; R-HSA-5683057; R-HSA-5684996; R-HSA-6785807; R-HSA-6806834; R-HSA-6811558; R-HSA-74751; R-HSA-74752; R-HSA-76002; R-HSA-8851907; R-HSA-8853334; R-HSA-8853338; R-HSA-8853659; R-HSA-8939211; R-HSA-9006115; R-HSA-9006335; R-HSA-9006925; R-HSA-9006931; R-HSA-9006934; R-HSA-9009391; R-HSA-9027276; R-HSA-9028335; R-HSA-9034015; R-HSA-912526; R-HSA-912631; R-HSA-9603381; R-HSA-9607240; R-HSA-9664565; R-HSA-9665348; R-HSA-9669938; R-HSA-9670439; R-HSA-9671555; R-HSA-9673767; R-HSA-9673770; R-HSA-9675108; R-HSA-9682385; R-HSA-9703465; R-HSA-9703648; R-HSA-983695; R-HSA-983705
1 combination linked to PIK3R1 OLI1712
1 variant linked to PIK3R1 PIK3R1:c.336+1G>A,
1 disease linked to PIK3R1 Common variable immunodeficiency
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