GENE NAME | OGG1 |
CHROMOSOME | 3 |
ENSEMBL ID | ENSG00000114026 |
ENTREZ ID | 4968 |
UNIPROT ACCESSION NUMBER | O15527 |
GO MOLECULAR FUNCTION | damaged DNA binding; endonuclease activity; oxidized purine nucleobase lesion DNA N-glycosylase activity; class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
ESSENTIAL IN MOUSE | Non-essential |
PATHWAYS | R-HSA-9656256; hsa03410; R-HSA-110329; R-HSA-5649702; hsa03410; R-HSA-110331; R-HSA-9656249; R-HSA-9656255; R-HSA-9675135; R-HSA-110330; R-HSA-73884; R-HSA-73927; R-HSA-73933; R-HSA-1643685; R-HSA-73894; R-HSA-110328; R-HSA-9605308; R-HSA-110357; R-HSA-73928; R-HSA-73929 |
2 combinations linked to OGG1 | OLI284; OLI188 |
2 variants linked to OGG1 | OGG1:c.137G>A, p.Arg46Gln; OGG1:c.923G>A, p.Gly308Glu |
2 diseases linked to OGG1 | Colorectal cancer; Familial adenomatous polyposis |