Details for Gene OGG1

GENE NAME OGG1
CHROMOSOME 3
ENSEMBL ID ENSG00000114026
ENTREZ ID 4968
UNIPROT ACCESSION NUMBER O15527
GO MOLECULAR FUNCTION damaged DNA binding; endonuclease activity; oxidized purine nucleobase lesion DNA N-glycosylase activity; class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ESSENTIAL IN MOUSE Non-essential
PATHWAYS R-HSA-9656256; hsa03410; R-HSA-110329; R-HSA-5649702; hsa03410; R-HSA-110331; R-HSA-9656249; R-HSA-9656255; R-HSA-9675135; R-HSA-110330; R-HSA-73884; R-HSA-73927; R-HSA-73933; R-HSA-1643685; R-HSA-73894; R-HSA-110328; R-HSA-9605308; R-HSA-110357; R-HSA-73928; R-HSA-73929
2 combinations linked to OGG1 OLI188; OLI284
2 variants linked to OGG1 OGG1:c.137G>A, p.Arg46Gln; OGG1:c.923G>A, p.Gly308Glu
2 diseases linked to OGG1 Colorectal cancer; Familial adenomatous polyposis

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