Details for Gene LRRK2

GENE NAME LRRK2
CHROMOSOME 12
ENSEMBL ID None
ENTREZ ID ENSG00000188906
UNIPROT ACCESSION NUMBER Q5S007
GO MOLECULAR FUNCTION ['signaling receptor complex adaptor activity', 'protein serine/threonine kinase activity', 'MAP kinase kinase kinase activity', 'protein serine kinase activity', 'microtubule binding', 'actin binding', 'protein binding', 'identical protein binding', 'tubulin binding', 'syntaxin-1 binding', 'GTPase activator activity', 'small GTPase binding', 'kinase activity', 'magnesium ion binding', 'beta-catenin destruction complex binding', 'co-receptor binding', 'GTPase activity', 'protein kinase activity', 'SNARE binding', 'JUN kinase kinase kinase activity', 'ATP binding', 'clathrin binding', 'peroxidase inhibitor activity', 'protein homodimerization activity', 'protein serine/threonine phosphatase activity', 'transmembrane transporter binding', 'GTP binding', 'GTP-dependent protein kinase activity', 'protein kinase A binding', 'protein serine/threonine/tyrosine kinase activity']
ESSENTIAL IN MOUSE Essential
PATHWAYS hsa05012; hsa05022; hsa05012; hsa05022; R-HSA-162582; R-HSA-8848021; R-HSA-8857538; R-HSA-9006927
1 combination linked to LRRK2 OLI1312
1 variant linked to LRRK2 LRRK2:p.Gly2019Ser
1 disease linked to LRRK2 Frontotemporal dementia

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