Details for Gene FZD4

GENE NAME FZD4
CHROMOSOME 11
ENSEMBL ID None
ENTREZ ID ENSG00000174804
UNIPROT ACCESSION NUMBER Q9ULV1
GO MOLECULAR FUNCTION ['amyloid-beta binding', 'signaling receptor activity', 'Wnt-protein binding', 'cytokine binding', 'ubiquitin protein ligase binding', 'G protein-coupled receptor activity', 'PDZ domain binding', 'Wnt-activated receptor activity', 'protein-containing complex binding', 'protein heterodimerization activity', 'protein binding', 'protein homodimerization activity', 'cytokine receptor activity']
ESSENTIAL IN MOUSE Non-essential
PATHWAYS hsa04150; hsa04310; hsa04390; hsa04550; hsa04916; hsa04934; hsa05010; hsa05022; hsa05165; hsa05200; hsa05205; hsa05217; hsa05224; hsa05225; hsa05226; R-HSA-162582; R-HSA-1643685; R-HSA-195721; R-HSA-199991; R-HSA-201681; R-HSA-372790; R-HSA-373080; R-HSA-3858494; R-HSA-4086398; R-HSA-4086400; R-HSA-4608870; R-HSA-4641263; R-HSA-4791275; R-HSA-500792; R-HSA-5099900; R-HSA-5340588; R-HSA-5653656; R-HSA-5663202; R-HSA-8856825; R-HSA-8856828
17 combinations linked to FZD4 OLI1253; OLI307; OLI308; OLI312; OLI1252; OLI453; OLI306; OLI313; OLI303; OLI419; OLI1258; OLI309; OLI304; OLI1257; OLI305; OLI1259; OLI455
18 variants linked to FZD4 FZD4:c.1282_1285del, p.Asp428fs; FZD4:c.313A>G, p.Met105Val; FZD4:c.182C>T, p.Thr61Ile; FZD4:c.1482G>A, p.Trp494Ter; FZD4:c.1078A>T, p.Ile360Phe; FZD4:c.1589G>A, p.Gly530Glu; FZD4:c.283C>G, p.Gln95Glu; FZD4:c.1463G>A, p.Gly488Asp; FZD4:c.476T>C, p.Met159Thr; FZD4:c.205C>T, p.His69Tyr; FZD4:c.1250G>A, p.Arg417Gln; FZD4:c.349T>C, p.Cys117Arg; FZD4:c.1501_1502delCT, p.Leu501SerfsTer533; FZD4:c.502C>T, p.Pro11Gln; FZD4:c.97C>T, p.Pro33Ser; FZD4:c.1221_1223del, p.Ala408del; FZD4:c.481G>C, p.Gly161Arg; FZD4:c.416G>C, p.Trp139Ser
1 disease linked to FZD4 Familial exudative vitreoretinopathy
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