Details for Gene FUS

GENE NAME FUS
CHROMOSOME 16
ENSEMBL ID None
ENTREZ ID ENSG00000089280
UNIPROT ACCESSION NUMBER P35637
GO MOLECULAR FUNCTION ['DNA binding', 'chromatin binding', "mRNA 3'-UTR binding", 'transcription coregulator activity', 'protein binding', 'RNA binding', 'transcription coactivator activity', 'metal ion binding', 'identical protein binding']
ESSENTIAL IN MOUSE Essential
PATHWAYS hsa03013; hsa03015; hsa03040; hsa05014; hsa05022; hsa05202; R-HSA-72163; R-HSA-72172; R-HSA-72203; R-HSA-8953854; hsa03013; hsa03015; hsa03040; hsa05014; hsa05022; hsa05202
17 combinations linked to FUS OLI776; OLI629; OLI775; OLI1307; OLI822; OLI970; OLI628; OLI642; OLI945; OLI1701; OLI643; OLI278; OLI660; OLI1633; OLI1306; OLI276; OLI627
13 variants linked to FUS FUS:c.1453C>T, p.Arg485Trp; FUS:c.1574C>T, p.Pro525Leu; FUS:c.41G>A, ; FUS:c.833-29C>T, ; FUS:c.*59G>A, None; FUS:c.*1998T>C, None; FUS:c.1550G>A, p.Arg517His; FUS:p.Ser135Asn; FUS:p.Arg269Trp; FUS:c.1471C>T, p.Arg491Cys; FUS:c.*910C>T, ; FUS:c.170_172del, p.Ser57del; FUS:p.Pro151Ser
3 diseases linked to FUS Frontotemporal dementia; Amyotrophic lateral sclerosis; Juvenile amyotrophic lateral sclerosis
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