| GENE NAME | APOE |
| CHROMOSOME | 19 |
| ENSEMBL ID | None |
| ENTREZ ID | ENSG00000130203 |
| UNIPROT ACCESSION NUMBER | P02649 |
| GO MOLECULAR FUNCTION | ['lipid binding', 'protein binding', 'tau protein binding', 'structural molecule activity', 'identical protein binding', 'amyloid-beta binding', 'metal chelating activity', 'low-density lipoprotein particle receptor binding', 'lipoprotein particle binding', 'very-low-density lipoprotein particle receptor binding', 'heparin binding', 'protein homodimerization activity', 'phospholipid binding', 'cholesterol transfer activity', 'phosphatidylcholine-sterol O-acyltransferase activator activity', 'protein-containing complex binding', 'signaling receptor binding', 'protein dimerization activity', 'lipid transporter activity', 'heparan sulfate proteoglycan binding', 'antioxidant activity'] |
| ESSENTIAL IN MOUSE | Non-essential |
| PATHWAYS | hsa04979; hsa05010; hsa04979; hsa05010; R-HSA-1236394; R-HSA-1251985; R-HSA-1430728; R-HSA-162582; R-HSA-174824; R-HSA-196854; R-HSA-212436; R-HSA-2173782; R-HSA-2187338; R-HSA-3000480; R-HSA-372790; R-HSA-381426; R-HSA-382551; R-HSA-388396; R-HSA-392499; R-HSA-418594; R-HSA-5653656; R-HSA-597592; R-HSA-6806667; R-HSA-73857; R-HSA-74160; R-HSA-8864260; R-HSA-8957275; R-HSA-8963888; R-HSA-8963898; R-HSA-8963899; R-HSA-8963901; R-HSA-8964026; R-HSA-8964043; R-HSA-8964058; R-HSA-9006931; R-HSA-9006934; R-HSA-9024446; R-HSA-9029569; R-HSA-975634 |
| 2 combinations linked to APOE | OLI1471; OLI1470 |
| 1 variant linked to APOE | APOE:c.388T>C, p.Cys130Arg |
| 1 disease linked to APOE | NON RARE IN EUROPE: Alzheimer disease |