| GENE NAME | AKR1C3 |
| CHROMOSOME | 10 |
| ENSEMBL ID | None |
| ENTREZ ID | ENSG00000196139 |
| UNIPROT ACCESSION NUMBER | P42330 |
| GO MOLECULAR FUNCTION | ['geranylgeranyl reductase activity', '15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity', 'ketosteroid monooxygenase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'androsterone dehydrogenase activity', '17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'ketoreductase activity', 'steroid dehydrogenase activity', 'D-threo-aldose 1-dehydrogenase activity', 'oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor', 'prostaglandin-F synthase activity', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'dihydrotestosterone 17-beta-dehydrogenase activity', 'phenanthrene 9,10-monooxygenase activity', 'prostaglandin H2 endoperoxidase reductase activity', 'delta4-3-oxosteroid 5beta-reductase activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'NAD-retinol dehydrogenase activity', 'bile acid binding', 'alditol:NADP+ 1-oxidoreductase activity', 'retinal dehydrogenase activity', 'NADP-retinol dehydrogenase activity', 'testosterone dehydrogenase (NAD+) activity', 'prostaglandin D2 11-ketoreductase activity', 'aldo-keto reductase (NADP) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity'] |
| ESSENTIAL IN MOUSE | Non-essential |
| PATHWAYS | hsa00140; hsa00590; hsa00790; hsa01100; hsa04913; hsa00140; hsa00590; hsa00790; hsa01100; hsa04913; R-HSA-1430728; R-HSA-162582; R-HSA-192105; R-HSA-193368; R-HSA-193775; R-HSA-193807; R-HSA-194068; R-HSA-196854; R-HSA-2142753; R-HSA-2162123; R-HSA-2187338; R-HSA-372790; R-HSA-388396; R-HSA-418594; R-HSA-5362517; R-HSA-5365859; R-HSA-556833; R-HSA-6806667; R-HSA-8957322; R-HSA-8978868; R-HSA-9006931; R-HSA-975634; hsa00140; hsa00590; hsa00790; hsa01100; hsa04913; hsa00140; hsa00590; hsa00790; hsa01100; hsa04913; R-HSA-1430728; R-HSA-162582; R-HSA-192105; R-HSA-193368; R-HSA-193775; R-HSA-193807; R-HSA-194068; R-HSA-196854; R-HSA-2142753; R-HSA-2162123; R-HSA-2187338; R-HSA-372790; R-HSA-388396; R-HSA-418594; R-HSA-5362517; R-HSA-5365859; R-HSA-556833; R-HSA-6806667; R-HSA-8957322; R-HSA-8978868; R-HSA-9006931; R-HSA-975634 |
| 3 combinations linked to AKR1C3 | OLI1543; OLI573; OLI1532 |
| 3 variants linked to AKR1C3 | AKR1C3:c.548A>G, p.Lys183Arg; AKR1C3:c.548A>T, p.Lys183Met; AKR1C3:c.36T>G, p.Asp12Glu |
| 2 diseases linked to AKR1C3 | Disorder of sex development; 46,XY disorder of sex development |