Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/KCNE1/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "366", "attributes": { "gene_relationship": [ "Directly interacting", "Same protein complex", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(KCNE1, KCNH2)", "(KCNE1, KCNQ1)" ], "common_pathways": [ "Muscle contraction", "Voltage gated Potassium channels", "Phase 3 - rapid repolarisation", "Neuronal System", "Phase 2 - plateau phase", "Cardiac conduction", "Adrenergic signaling in cardiomyocytes" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:04.769938" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI549" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/366/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/366/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "KCNE1" }, { "type": "Gene", "id": "KCNH2" }, { "type": "Gene", "id": "KCNQ1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/366/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/366/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/366/?format=api" } }, { "type": "GeneCombination", "id": "367", "attributes": { "gene_relationship": [ "Directly interacting", "Same protein complex", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(KCNE1, KCNH2)" ], "common_pathways": [ "Phase 3 - rapid repolarisation", "Cardiac conduction" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:04.813034" }, "relationships": { "combination_set": { "meta": { "count": 8 }, "data": [ { "type": "Combination", "id": "OLI551" }, { "type": "Combination", "id": "OLI1220" }, { "type": "Combination", "id": "OLI1221" }, { "type": "Combination", "id": "OLI1222" }, { "type": "Combination", "id": "OLI1223" }, { "type": "Combination", "id": "OLI1224" }, { "type": "Combination", "id": "OLI1225" }, { "type": "Combination", "id": "OLI1226" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/367/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/367/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "KCNE1" }, { "type": "Gene", "id": "KCNH2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/367/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/367/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/367/?format=api" } }, { "type": "GeneCombination", "id": "861", "attributes": { "gene_relationship": [ "Involved in the same disease", "Directly interacting", "Affecting the same tissue", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(KCNE1, KCNQ1)" ], "common_pathways": [ "Phase 3 - rapid repolarisation", "Phase 2 - plateau phase", "Muscle contraction", "Cardiac conduction", "Adrenergic signaling in cardiomyocytes" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T14:49:08.532784" }, "relationships": { "combination_set": { "meta": { "count": 4 }, "data": [ { "type": "Combination", "id": "OLI1216" }, { "type": "Combination", "id": "OLI1217" }, { "type": "Combination", "id": "OLI1218" }, { "type": "Combination", "id": "OLI1219" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/861/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/861/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "KCNE1" }, { "type": "Gene", "id": "KCNQ1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/861/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/861/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/861/?format=api" } }, { "type": "GeneCombination", "id": "862", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Muscle contraction", "Adrenergic signaling in cardiomyocytes", "Cardiac conduction" ], "genecomb_metascore": 1, "lastmodified": "2024-03-01T14:50:05.794335" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI1227" }, { "type": "Combination", "id": "OLI1228" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/862/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/862/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "KCNE1" }, { "type": "Gene", "id": "SCN5A" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/862/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/862/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/862/?format=api" } } ] }