Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/FZD4/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "204", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Same pathway", "Affecting the same tissue" ], "protein_interactions": [], "common_pathways": [ "Signaling by WNT in cancer", "Regulation of FZD by ubiquitination", "Gastric cancer", "mTOR signaling pathway", "Breast cancer", "Disease", "Pathways of neurodegeneration - multiple diseases", "Pathways in cancer", "Alzheimer disease", "Hepatocellular carcinoma", "Signaling by RNF43 mutants", "Wnt signaling pathway", "Signaling by WNT", "Signal Transduction", "TCF dependent signaling in response to WNT", "Diseases of signal transduction by growth factor receptors and second messengers" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T15:02:30.424647" }, "relationships": { "combination_set": { "meta": { "count": 11 }, "data": [ { "type": "Combination", "id": "OLI303" }, { "type": "Combination", "id": "OLI304" }, { "type": "Combination", "id": "OLI305" }, { "type": "Combination", "id": "OLI306" }, { "type": "Combination", "id": "OLI307" }, { "type": "Combination", "id": "OLI308" }, { "type": "Combination", "id": "OLI309" }, { "type": "Combination", "id": "OLI419" }, { "type": "Combination", "id": "OLI1252" }, { "type": "Combination", "id": "OLI1253" }, { "type": "Combination", "id": "OLI1257" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/204/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/204/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FZD4" }, { "type": "Gene", "id": "LRP5" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/204/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/204/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/204/?format=api" } }, { "type": "GeneCombination", "id": "206", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Affecting the same tissue" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2024-03-01T15:02:18.776324" }, "relationships": { "combination_set": { "meta": { "count": 3 }, "data": [ { "type": "Combination", "id": "OLI312" }, { "type": "Combination", "id": "OLI313" }, { "type": "Combination", "id": "OLI1259" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/206/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/206/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FZD4" }, { "type": "Gene", "id": "ZNF408" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/206/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/206/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/206/?format=api" } }, { "type": "GeneCombination", "id": "310", "attributes": { "gene_relationship": [ "Indirectly interacting", "Directly interacting", "Same protein complex", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(FZD4, TSPAN12)" ], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:01.562488" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI453" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/310/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/310/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FZD4" }, { "type": "Gene", "id": "TSPAN12" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/310/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/310/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/310/?format=api" } }, { "type": "GeneCombination", "id": "311", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Membrane Trafficking", "Vesicle-mediated transport" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:01.616593" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI455" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/311/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/311/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "F5" }, { "type": "Gene", "id": "FZD4" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/311/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/311/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/311/?format=api" } }, { "type": "GeneCombination", "id": "884", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Same pathway", "Affecting the same tissue" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2024-03-01T14:39:12.624516" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1258" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/884/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/884/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "FZD4" }, { "type": "Gene", "id": "LRP5" }, { "type": "Gene", "id": "ZNF408" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/884/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/884/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/884/?format=api" } } ] }