Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/FN1/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "863",
            "attributes": {
                "gene_relationship": [
                    "Monogenic experiments only",
                    "Involved in the same disease",
                    "Affecting the same tissue",
                    "Same pathway",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [
                    "(FN1, ITGAV)"
                ],
                "common_pathways": [
                    "Non-integrin membrane-ECM interactions",
                    "Integrin cell surface interactions",
                    "Regulation of actin cytoskeleton",
                    "Extracellular matrix organization",
                    "Immune System",
                    "Elastic fibre formation",
                    "Signal Transduction",
                    "Molecules associated with elastic fibres",
                    "ECM-receptor interaction",
                    "Syndecan interactions",
                    "Pathways in cancer",
                    "Small cell lung cancer",
                    "Focal adhesion",
                    "Signaling by Receptor Tyrosine Kinases",
                    "PI3K-Akt signaling pathway",
                    "Human papillomavirus infection",
                    "Proteoglycans in cancer",
                    "ECM proteoglycans",
                    "Cell surface interactions at the vascular wall",
                    "Hemostasis"
                ],
                "genecomb_metascore": 2,
                "lastmodified": "2024-03-01T15:19:57.782883"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1230"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/863/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/863/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "FN1"
                        },
                        {
                            "type": "Gene",
                            "id": "ITGAV"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/863/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/863/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/863/?format=api"
            }
        }
    ]
}