Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/BBS9/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "63", "attributes": { "gene_relationship": [ "Involved in the same disease", "Similar function", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(BBS12, MKKS)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:48.091017" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI087" }, { "type": "Combination", "id": "OLI1131" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/63/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/63/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS12" }, { "type": "Gene", "id": "BBS9" }, { "type": "Gene", "id": "MKKS" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/63/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/63/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/63/?format=api" } }, { "type": "GeneCombination", "id": "105", "attributes": { "gene_relationship": [ "Directly interacting", "Same protein complex", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(BBS1, BBS9)" ], "common_pathways": [ "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:49.977652" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI141" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/105/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/105/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS1" }, { "type": "Gene", "id": "BBS9" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/105/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/105/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/105/?format=api" } }, { "type": "GeneCombination", "id": "278", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:00.331931" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI418" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/278/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/278/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS10" }, { "type": "Gene", "id": "BBS9" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/278/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/278/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/278/?format=api" } }, { "type": "GeneCombination", "id": "421", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype" ], "protein_interactions": [ "(BBS4, BBS9)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:01:08.062866" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI615" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/421/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/421/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "ALMS1" }, { "type": "Gene", "id": "BBS4" }, { "type": "Gene", "id": "BBS9" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/421/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/421/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/421/?format=api" } }, { "type": "GeneCombination", "id": "821", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same protein complex", "Directly interacting", "Affecting the same tissue", "Same pathway" ], "protein_interactions": [ "(BBS9, BBS4)" ], "common_pathways": [ "Organelle biogenesis and maintenance", "Cilium Assembly", "BBSome-mediated cargo-targeting to cilium", "Cargo trafficking to the periciliary membrane" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T14:52:29.986369" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI1123" }, { "type": "Combination", "id": "OLI1133" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/821/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/821/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS4" }, { "type": "Gene", "id": "BBS9" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/821/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/821/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/821/?format=api" } }, { "type": "GeneCombination", "id": "1021", "attributes": { "gene_relationship": [], "protein_interactions": [ "(BBS9, CEP290)" ], "common_pathways": [ "Organelle biogenesis and maintenance", "Cilium Assembly" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:27.551098" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1452" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1021/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1021/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS9" }, { "type": "Gene", "id": "CEP290" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1021/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1021/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1021/?format=api" } }, { "type": "GeneCombination", "id": "1020", "attributes": { "gene_relationship": [ "Colocalization", "Same pathway", "Involved in the same disease" ], "protein_interactions": [ "(BBS7, BBS9)" ], "common_pathways": [ "BBSome-mediated cargo-targeting to cilium", "Cilium Assembly", "Organelle biogenesis and maintenance", "Cargo trafficking to the periciliary membrane" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T14:20:56.317751" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1451" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1020/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1020/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS7" }, { "type": "Gene", "id": "BBS9" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1020/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1020/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1020/?format=api" } } ] }