Combination List
This API endpoint handles listing (/combinations) and retrieval (/combinations/{combination_pk}/) of oligogenic combinations from the database
GET /api/diseases/3140/combinations/?format=api
{ "data": [ { "type": "Combination", "id": "OLI1697", "attributes": { "scores": { "familial_evidence": 1, "statistical_evidence_manual": 2, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 2, "functional_gene_evidence_manual": 0, "functional_gene_evidence_manual_harmonized": 0, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 0, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 0, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2024-02-29T15:02:30.429766" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "3140" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1697/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1697/diseases/?format=api" } }, "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "3593" }, { "type": "SmallVariant", "id": "3594" }, { "type": "SmallVariant", "id": "3595" }, { "type": "SmallVariant", "id": "3596" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1697/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1697/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "983" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1697/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1697/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1697/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1697/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "1210" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1697/?format=api" } }, { "type": "Combination", "id": "OLI553", "attributes": { "scores": { "familial_evidence": 1, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 1, "functional_gene_evidence_manual_harmonized": 1, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 1, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 1, "functional_final_metascore": 1, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "Indian", "lastmodified": "2021-11-16T17:59:47.387558" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "3140" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI553/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI553/diseases/?format=api" } }, "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1152" }, { "type": "SmallVariant", "id": "1153" }, { "type": "SmallVariant", "id": "1154" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI553/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI553/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "811" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI553/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI553/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI553/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI553/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "369" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI553/?format=api" } }, { "type": "Combination", "id": "OLI554", "attributes": { "scores": { "familial_evidence": 1, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 2, "functional_final_metascore": 2, "final_manual": 1, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Monogenic+Modifier", "status": "CU", "effect_predicted": false, "ethnicity": "Indian", "lastmodified": "2021-11-16T17:59:47.408489" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "3140" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI554/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI554/diseases/?format=api" } }, "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1155" }, { "type": "SmallVariant", "id": "1156" }, { "type": "SmallVariant", "id": "1157" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI554/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI554/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "811" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI554/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI554/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI554/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI554/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "370" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI554/?format=api" } }, { "type": "Combination", "id": "OLI646", "attributes": { "scores": { "familial_evidence": 1, "statistical_evidence_manual": 1, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 1, "functional_gene_evidence_manual_harmonized": 1, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 1, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 1, "functional_final_metascore": 1, "final_manual": 1, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "South Asian", "lastmodified": "2021-11-16T17:59:49.531257" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "3140" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI646/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI646/diseases/?format=api" } }, "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1396" }, { "type": "SmallVariant", "id": "1397" }, { "type": "SmallVariant", "id": "1398" }, { "type": "SmallVariant", "id": "1399" }, { "type": "SmallVariant", "id": "1400" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI646/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI646/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "810" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI646/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI646/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI646/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI646/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "440" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI646/?format=api" } }, { "type": "Combination", "id": "OLI934", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 1, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 1, "functional_gene_evidence_manual_harmonized": 1, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 1, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 1, "functional_final_metascore": 1, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2022-08-04T14:15:09.678765" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "3140" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI934/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI934/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2021" }, { "type": "SmallVariant", "id": "2022" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI934/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI934/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "875" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI934/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI934/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI934/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI934/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "696" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI934/?format=api" } }, { "type": "Combination", "id": "OLI935", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 1, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 1, "functional_gene_evidence_manual_harmonized": 1, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 1, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 1, "functional_final_metascore": 1, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2022-08-04T14:15:09.853804" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "3140" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI935/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI935/diseases/?format=api" } }, "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2023" }, { "type": "SmallVariant", "id": "2024" }, { "type": "SmallVariant", "id": "2025" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI935/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI935/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "875" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI935/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI935/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI935/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI935/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "697" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI935/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 6 } }