Gene

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{
    "data": {
        "type": "Gene",
        "id": "APEX1",
        "attributes": {
            "go_molecular_function": [
                "[\"3'-5' exonuclease activity\", 'transcription corepressor activity', 'chromatin DNA binding', 'DNA-(abasic site) binding', \"double-stranded DNA 3'-5' exodeoxyribonuclease activity\", 'RNA binding', 'RNA-DNA hybrid ribonuclease activity', 'phosphoric diester hydrolase activity', 'site-specific endodeoxyribonuclease activity, specific for altered base', 'DNA-(apurinic or apyrimidinic site) endonuclease activity', 'endonuclease activity', 'double-stranded DNA exodeoxyribonuclease activity', \"3'-5'-exodeoxyribonuclease activity\", 'protein-containing complex binding', \"phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands\", 'endodeoxyribonuclease activity', 'NF-kappaB binding', 'double-stranded telomeric DNA binding', 'metal ion binding', 'DNA binding', 'class II DNA-(apurinic or apyrimidinic site) endonuclease activity', 'oxidoreductase activity', 'uracil DNA N-glycosylase activity', 'damaged DNA binding', 'protein binding', 'transcription coactivator activity', 'phosphodiesterase I activity']"
            ],
            "pathway_id": [
                "kegg_path:hsa03410",
                "R-HSA-110357",
                "R-HSA-110362",
                "R-HSA-110373",
                "R-HSA-110381",
                "R-HSA-5651801",
                "R-HSA-73884",
                "R-HSA-73894",
                "R-HSA-73930",
                "R-HSA-73933",
                "kegg_path:hsa03410"
            ],
            "essential_gene": "Essential",
            "status": null,
            "uniprot_acc": "P27695",
            "ensembl_id": "None",
            "entrez_id": "ENSG00000100823",
            "chromosome_number": "14"
        },
        "relationships": {
            "variant_set": {
                "meta": {
                    "count": 2
                },
                "data": [
                    {
                        "type": "SmallVariant",
                        "id": "2095"
                    },
                    {
                        "type": "SmallVariant",
                        "id": "3564"
                    }
                ],
                "links": {
                    "self": "https://olida.ibsquare.be/api/genes/APEX1/relationships/variant_set?format=api",
                    "related": "https://olida.ibsquare.be/api/genes/APEX1/variants/?format=api"
                }
            },
            "genecombination_set": {
                "meta": {
                    "count": 2
                },
                "data": [
                    {
                        "type": "GeneCombination",
                        "id": "725"
                    },
                    {
                        "type": "GeneCombination",
                        "id": "1200"
                    }
                ],
                "links": {
                    "self": "https://olida.ibsquare.be/api/genes/APEX1/relationships/genecombination_set?format=api",
                    "related": "https://olida.ibsquare.be/api/genes/APEX1/genecombinations/?format=api"
                }
            }
        },
        "links": {
            "self": "https://olida.ibsquare.be/api/genes/APEX1/?format=api"
        }
    },
    "meta": {
        "database_name": "OLIgogenic diseases DAtabase (OLIDA)",
        "resource_url": "olida.ibsquare.be",
        "api_release_year": "2021",
        "api_developer": [
            [
                "Arnau Dillen",
                "arnau.dillen@ulb.ac.be"
            ],
            [
                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
            ]
        ],
        "api_version": "0.3",
        "api_maintainers": [
            [
                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
            ]
        ],
        "api_documentation": [
            "olida.ibsquare.be/api/swagger",
            "olida.ibsquare.be/api/redoc"
        ],
        "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.",
        "license": "CC Attribution-NonCommercial 4.0 International License",
        "ontologies": {
            "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO",
            "GENO": "http://purl.obolibrary.org/obo/geno.owl",
            "MI": "http://purl.obolibrary.org/obo/mi.owl",
            "NCIT": "http://purl.obolibrary.org/obo/ncit.owl",
            "OGI": "http://purl.obolibrary.org/obo/ogi.owl",
            "OGG": "http://purl.obolibrary.org/obo/ogg.owl"
        },
        "relevant_publications_doi": [
            "10.1093/nar/gkv1068",
            "10.1093/database/baac023"
        ],
        "lastmodified": "2022-08-04T14:14:59.361563",
        "status": "CU",
        "curator": null,
        "submitter": "cnachteg"
    }
}