Gene
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/variants/2608/gene/?format=api
{ "data": { "type": "Gene", "id": "HSF1", "attributes": { "go_molecular_function": [ "['STAT family protein binding', 'sequence-specific single stranded DNA binding', 'transcription cis-regulatory region binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'DNA binding', 'general transcription initiation factor binding', 'protein binding', 'identical protein binding', 'DNA-binding transcription factor activity', 'sequence-specific DNA binding', 'heat shock protein binding', 'protein heterodimerization activity', 'Hsp90 protein binding', 'chromatin DNA binding', 'sequence-specific double-stranded DNA binding', 'DNA-binding transcription repressor activity, RNA polymerase II-specific', 'translation elongation factor binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'protein kinase binding', 'protein self-association', 'RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding', 'promoter-specific chromatin binding']" ], "pathway_id": [ "kegg_path:hsa05134", "R-HSA-1632852", "R-HSA-2262752", "R-HSA-3371453", "R-HSA-3371511", "R-HSA-3371556", "R-HSA-3371568", "R-HSA-3371571", "R-HSA-8953897", "R-HSA-9612973", "R-HSA-9646399", "R-HSA-9663891", "kegg_path:hsa05134", "R-HSA-1632852", "R-HSA-2262752", "R-HSA-3371453", "R-HSA-3371511", "R-HSA-3371556", "R-HSA-3371568", "R-HSA-3371571", "R-HSA-8953897", "R-HSA-9612973", "R-HSA-9646399", "R-HSA-9663891" ], "essential_gene": "Essential", "status": null, "uniprot_acc": "Q00613", "ensembl_id": "None", "entrez_id": "ENSG00000185122", "chromosome_number": "8" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2608" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSF1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSF1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "865" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSF1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSF1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HSF1/?format=api" } }, "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "lastmodified": "2023-05-16T12:02:32.372530", "status": "CU", "curator": null, "submitter": "cnachteg" } }