Gene
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/variants/2306/gene/?format=api
{ "data": { "type": "Gene", "id": "TP53", "attributes": { "go_molecular_function": [ "protease binding", "DNA-binding transcription activator activity", "enzyme binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "copper ion binding", "histone deacetylase binding", "cis-regulatory region sequence-specific DNA binding", "ATP-dependent DNA/DNA annealing activity", "histone acetyltransferase binding", "protein heterodimerization activity", "receptor tyrosine kinase binding", "protein phosphatase 2A binding", "protein binding", "mRNA 3'-UTR binding", "identical protein binding", "core promoter sequence-specific DNA binding", "disordered domain specific binding", "chromatin binding", "RNA polymerase II-specific DNA-binding transcription factor binding", "histone deacetylase regulator activity", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "TFIID-class transcription factor complex binding", "protein kinase binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "transcription cis-regulatory region binding", "p53 binding", "DNA binding", "ubiquitin protein ligase binding", "chaperone binding", "promoter-specific chromatin binding", "DNA-binding transcription factor activity", "protein self-association", "protein phosphatase binding", "general transcription initiation factor binding", "protein N-terminus binding", "DNA-binding transcription repressor activity, RNA polymerase II-specific", "MDM2/MDM4 family protein binding", "zinc ion binding" ], "pathway_id": [ "kegg_path:hsa04310", "kegg_path:hsa05016", "kegg_path:hsa04137", "kegg_path:hsa05219", "kegg_path:hsa05205", "R-HSA-109606", "R-HSA-6811555", "R-HSA-74160", "kegg_path:hsa05213", "kegg_path:hsa05223", "kegg_path:hsa05214", "R-HSA-5693532", "R-HSA-8853884", "R-HSA-1280215", "R-HSA-453274", "kegg_path:hsa05202", "kegg_path:hsa04211", "R-HSA-69560", "kegg_path:hsa05224", "R-HSA-6804754", "R-HSA-6806003", "kegg_path:hsa05212", "kegg_path:hsa04151", "R-HSA-6804760", "kegg_path:hsa05012", "kegg_path:hsa05203", "R-HSA-349425", "kegg_path:hsa05215", "kegg_path:hsa05200", "kegg_path:hsa04722", "kegg_path:hsa05162", "kegg_path:hsa05210", "R-HSA-449147", "kegg_path:hsa04218", "R-HSA-8878159", "kegg_path:hsa05166", "R-HSA-9006925", "kegg_path:hsa04210", "R-HSA-5688426", "kegg_path:hsa05218", "kegg_path:hsa05169", "kegg_path:hsa05161", "R-HSA-6804759", "kegg_path:hsa05230", "R-HSA-5628897", "R-HSA-8852276", "kegg_path:hsa05220", "R-HSA-69473", "kegg_path:hsa05166", "kegg_path:hsa04218", "kegg_path:hsa05210", "kegg_path:hsa05162", "R-HSA-983231", "kegg_path:hsa05200", "kegg_path:hsa04722", "kegg_path:hsa05215", "R-HSA-8953897", "kegg_path:hsa05203", "R-HSA-1912408", "R-HSA-5357801", "R-HSA-6796648", "kegg_path:hsa05220", "R-HSA-69563", "kegg_path:hsa05230", "kegg_path:hsa05161", "kegg_path:hsa05218", "R-HSA-69541", "kegg_path:hsa05169", "R-HSA-6804756", "R-HSA-73894", "kegg_path:hsa04210", "R-HSA-8943724", "kegg_path:hsa05214", "R-HSA-6804758", "kegg_path:hsa05213", "kegg_path:hsa05223", "R-HSA-212436", "kegg_path:hsa05205", "kegg_path:hsa05219", "kegg_path:hsa04137", "kegg_path:hsa04310", "kegg_path:hsa05016", "R-HSA-109581", "R-HSA-6785807", "R-HSA-390471", "R-HSA-6804115", "R-HSA-73857", "kegg_path:hsa05012", "kegg_path:hsa05212", "kegg_path:hsa04151", "R-HSA-391251", "kegg_path:hsa05224", "kegg_path:hsa05202", "kegg_path:hsa04211", "R-HSA-168256", "R-HSA-390466", "R-HSA-2559583", "kegg_path:hsa05014", "kegg_path:hsa05160", "R-HSA-111448", "R-HSA-5689880", "R-HSA-2990846", "R-HSA-6803205", "R-HSA-3700989", "R-HSA-69481", "R-HSA-69275", "kegg_path:hsa05216", "kegg_path:hsa05165", "kegg_path:hsa04010", "kegg_path:hsa05418", "kegg_path:hsa05168", "kegg_path:hsa05226", "R-HSA-2559586", "R-HSA-157118", "kegg_path:hsa01524", "kegg_path:hsa05206", "R-HSA-1912422", "R-HSA-6804757", "R-HSA-69615", "R-HSA-2559585", "R-HSA-2559580", "kegg_path:hsa05222", "kegg_path:hsa04071", "kegg_path:hsa05131", "R-HSA-139915", "R-HSA-3108232", "R-HSA-6791312", "kegg_path:hsa04115", "R-HSA-6807070", "R-HSA-6803204", "kegg_path:hsa01522", "R-HSA-5693606", "R-HSA-6803207", "kegg_path:hsa05163", "R-HSA-1257604", "R-HSA-3232118", "kegg_path:hsa04919", "R-HSA-69620", "kegg_path:hsa04110", "kegg_path:hsa05217", "R-HSA-2559584", "R-HSA-6804114", "kegg_path:hsa04216", "kegg_path:hsa05225", "R-HSA-6803211", "R-HSA-69278", "kegg_path:hsa05167", "R-HSA-6804116", "kegg_path:hsa05163", "kegg_path:hsa01522", "R-HSA-69895", "kegg_path:hsa04115", "kegg_path:hsa04071", "kegg_path:hsa05131", "R-HSA-2262752", "kegg_path:hsa05222", "R-HSA-5633008", "R-HSA-114452", "R-HSA-162582", "kegg_path:hsa05167", "kegg_path:hsa04216", "kegg_path:hsa05225", "R-HSA-109582", "R-HSA-8941855", "kegg_path:hsa05217", "kegg_path:hsa04110", "kegg_path:hsa04919", "kegg_path:hsa05168", "kegg_path:hsa05216", "R-HSA-5633007", "R-HSA-5689896", "kegg_path:hsa04010", "kegg_path:hsa05418", "kegg_path:hsa05165", "R-HSA-1640170", "R-HSA-597592", "kegg_path:hsa05160", "kegg_path:hsa05014", "R-HSA-69580", "R-HSA-392499", "kegg_path:hsa01524", "R-HSA-5693565", "kegg_path:hsa05206", "kegg_path:hsa05226" ], "essential_gene": "Essential", "status": null, "uniprot_acc": "P04637", "ensembl_id": "ENSG00000141510", "entrez_id": "7157", "chromosome_number": "17" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1670" }, { "type": "SmallVariant", "id": "2306" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TP53/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TP53/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "544" }, { "type": "GeneCombination", "id": "774" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TP53/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TP53/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TP53/?format=api" } }, "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "lastmodified": "2021-10-18T11:00:44.483971", "status": "CU", "curator": null, "submitter": "cnachteg" } }