Gene
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/variants/2176/gene/?format=api
{ "data": { "type": "Gene", "id": "ESR1", "attributes": { "go_molecular_function": [ "transcription coactivator binding", "steroid binding", "enzyme binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "beta-catenin binding", "transcription corepressor binding", "protein binding", "TBP-class protein binding", "identical protein binding", "chromatin binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "protein kinase binding", "transcription coregulator binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity", "nuclear receptor activity", "estrogen response element binding", "nitric-oxide synthase regulator activity", "TFIIB-class transcription factor binding", "estrogen receptor binding", "estrogen receptor activity", "ATPase binding", "zinc ion binding" ], "pathway_id": [ "kegg_path:hsa05224", "R-HSA-5688426", "R-HSA-73857", "R-HSA-383280", "R-HSA-8939256", "R-HSA-8878171", "kegg_path:hsa04919", "R-HSA-8939211", "R-HSA-2219528", "R-HSA-392499", "kegg_path:hsa04917", "kegg_path:hsa01522", "R-HSA-2990846", "R-HSA-3108232", "kegg_path:hsa05205", "R-HSA-212436", "R-HSA-6811558", "R-HSA-9006931", "kegg_path:hsa05205", "R-HSA-5689896", "kegg_path:hsa01522", "kegg_path:hsa04961", "R-HSA-9009391", "kegg_path:hsa04917", "R-HSA-1257604", "R-HSA-4090294", "R-HSA-162582", "R-HSA-8866910", "R-HSA-8939902", "R-HSA-9006925", "kegg_path:hsa04915", "R-HSA-8864260", "kegg_path:hsa05200", "R-HSA-1236394", "kegg_path:hsa05200", "R-HSA-597592", "kegg_path:hsa04915", "R-HSA-1251985", "R-HSA-8878166", "R-HSA-5663202", "R-HSA-74160", "R-HSA-199418", "R-HSA-9006934", "kegg_path:hsa05224", "R-HSA-8931987", "kegg_path:hsa04919", "R-HSA-2219530", "R-HSA-1643685", "R-HSA-9018519", "kegg_path:hsa04961" ], "essential_gene": "Non-essential", "status": null, "uniprot_acc": "P03372", "ensembl_id": "ENSG00000091831", "entrez_id": "2099", "chromosome_number": "6" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2176" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ESR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ESR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "741" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ESR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ESR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ESR1/?format=api" } }, "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "lastmodified": "2022-08-04T14:14:58.969659", "status": "CU", "curator": null, "submitter": "cnachteg" } }