Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/TNNT2/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "277",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Affecting the same tissue",
                    "Same pathway",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [
                    "Dilated cardiomyopathy",
                    "Hypertrophic cardiomyopathy",
                    "Cardiac muscle contraction"
                ],
                "genecomb_metascore": 2,
                "lastmodified": "2021-10-18T11:01:00.276749"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI416"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI1212"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/277/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/277/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "MYH7"
                        },
                        {
                            "type": "Gene",
                            "id": "TNNT2"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/277/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/277/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/277/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1274",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Indirectly interacting"
                ],
                "protein_interactions": [],
                "common_pathways": [
                    "Muscle contraction",
                    "Dilated cardiomyopathy",
                    "Hypertrophic cardiomyopathy",
                    "Striated Muscle Contraction"
                ],
                "genecomb_metascore": 1,
                "lastmodified": "2024-02-29T15:02:23.901316"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1799"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1274/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1274/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "TNNT2"
                        },
                        {
                            "type": "Gene",
                            "id": "TTN"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1274/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1274/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1274/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1275",
            "attributes": {
                "gene_relationship": [],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 0,
                "lastmodified": "2024-02-29T15:02:23.921635"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1800"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1275/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1275/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "DSC2"
                        },
                        {
                            "type": "Gene",
                            "id": "TNNT2"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1275/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1275/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1275/?format=api"
            }
        }
    ]
}