Gene Instance
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genes/TBP/?format=api
{ "data": { "type": "Gene", "id": "TBP", "attributes": { "go_molecular_function": [ "['general transcription initiation factor activity', 'core promoter sequence-specific DNA binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'RNA polymerase II general transcription initiation factor activity', 'RNA polymerase III general transcription initiation factor activity', 'enzyme binding', 'TFIIB-class transcription factor binding', 'transcription cis-regulatory region binding', 'protein binding', 'RNA polymerase II core promoter sequence-specific DNA binding', 'aryl hydrocarbon receptor binding', 'DNA-binding transcription factor binding', 'RNA polymerase II general transcription initiation factor binding']" ], "pathway_id": [ "kegg_path:hsa03022", "kegg_path:hsa05016", "kegg_path:hsa05017", "kegg_path:hsa05165", "kegg_path:hsa05166", "kegg_path:hsa05203", "R-HSA-162582", "R-HSA-162587", "R-HSA-162599", "R-HSA-162906", "R-HSA-1643685", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-212165", "R-HSA-212436", "R-HSA-3700989", "R-HSA-427359", "R-HSA-427413", "R-HSA-5250913", "R-HSA-5250924", "R-HSA-5250941", "R-HSA-5633007", "R-HSA-5663205", "R-HSA-674695", "R-HSA-6804756", "R-HSA-6807505", "R-HSA-73762", "R-HSA-73772", "R-HSA-73776", "R-HSA-73779", "R-HSA-73854", "R-HSA-73857", "R-HSA-73863", "R-HSA-73864", "R-HSA-74158", "R-HSA-74160", "R-HSA-749476", "R-HSA-75953", "R-HSA-76042", "R-HSA-76046", "R-HSA-76061", "R-HSA-76066", "R-HSA-76071", "R-HSA-8939211", "R-HSA-9006931", "R-HSA-9018519", "kegg_path:hsa03022", "kegg_path:hsa05016", "kegg_path:hsa05017", "kegg_path:hsa05165", "kegg_path:hsa05166", "kegg_path:hsa05203" ], "essential_gene": "Essential", "status": null, "uniprot_acc": "P20226", "ensembl_id": "None", "entrez_id": "ENSG00000112592", "chromosome_number": "6" }, "relationships": { "variant_set": { "meta": { "count": 21 }, "data": [ { "type": "CopyNumberVariant", "id": "2526" }, { "type": "CopyNumberVariant", "id": "2528" }, { "type": "CopyNumberVariant", "id": "2530" }, { "type": "CopyNumberVariant", "id": "2532" }, { "type": "CopyNumberVariant", "id": "2535" }, { "type": "CopyNumberVariant", "id": "2540" }, { "type": "CopyNumberVariant", "id": "2543" }, { "type": "CopyNumberVariant", "id": "2546" }, { "type": "CopyNumberVariant", "id": "2549" }, { "type": "CopyNumberVariant", "id": "2550" }, { "type": "CopyNumberVariant", "id": "2552" }, { "type": "CopyNumberVariant", "id": "2553" }, { "type": "CopyNumberVariant", "id": "2556" }, { "type": "CopyNumberVariant", "id": "2557" }, { "type": "CopyNumberVariant", "id": "2559" }, { "type": "CopyNumberVariant", "id": "2562" }, { "type": "CopyNumberVariant", "id": "2564" }, { "type": "CopyNumberVariant", "id": "2567" }, { "type": "CopyNumberVariant", "id": "2569" }, { "type": "CopyNumberVariant", "id": "2571" }, { "type": "CopyNumberVariant", "id": "2869" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TBP/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TBP/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "857" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TBP/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TBP/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TBP/?format=api" } }, "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "lastmodified": "2022-05-12T19:40:43.184526", "status": "CU", "curator": null, "submitter": "cnachteg" } }