Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/TBK1/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "248", "attributes": { "gene_relationship": [ "Directly interacting", "Same protein complex", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway", "Similar function" ], "protein_interactions": [ "(OPTN, TBK1)" ], "common_pathways": [ "Amyotrophic lateral sclerosis", "Pathways of neurodegeneration - multiple diseases", "Mitophagy - animal" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:58.219360" }, "relationships": { "combination_set": { "meta": { "count": 3 }, "data": [ { "type": "Combination", "id": "OLI360" }, { "type": "Combination", "id": "OLI641" }, { "type": "Combination", "id": "OLI644" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/248/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/248/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "OPTN" }, { "type": "Gene", "id": "TBK1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/248/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/248/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/248/?format=api" } }, { "type": "GeneCombination", "id": "438", "attributes": { "gene_relationship": [ "Involved in the same disease", "Monogenic experiments only", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Amyotrophic lateral sclerosis", "Pathways of neurodegeneration - multiple diseases" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:01:08.898662" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI642" }, { "type": "Combination", "id": "OLI643" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/438/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/438/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "FUS" }, { "type": "Gene", "id": "TBK1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/438/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/438/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/438/?format=api" } }, { "type": "GeneCombination", "id": "599", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:01:18.177705" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI826" }, { "type": "Combination", "id": "OLI1627" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/599/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/599/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "NEK1" }, { "type": "Gene", "id": "TBK1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/599/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/599/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/599/?format=api" } }, { "type": "GeneCombination", "id": "1147", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Pathways of neurodegeneration - multiple diseases", "Amyotrophic lateral sclerosis", "Autophagy - animal" ], "genecomb_metascore": 2, "lastmodified": "2024-02-29T15:02:21.303061" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI1622" }, { "type": "Combination", "id": "OLI1624" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1147/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1147/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "C9orf72" }, { "type": "Gene", "id": "TBK1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1147/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1147/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1147/?format=api" } }, { "type": "GeneCombination", "id": "1212", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [ "(OPTN, SOD1)", "(OPTN, TBK1)" ], "common_pathways": [ "Pathways of neurodegeneration - multiple diseases", "Amyotrophic lateral sclerosis" ], "genecomb_metascore": 2, "lastmodified": "2024-02-29T15:02:22.625157" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1699" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1212/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1212/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "OPTN" }, { "type": "Gene", "id": "SOD1" }, { "type": "Gene", "id": "TBK1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1212/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1212/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1212/?format=api" } }, { "type": "GeneCombination", "id": "1227", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2024-02-29T15:02:22.934234" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1718" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1227/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1227/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "IGLL1" }, { "type": "Gene", "id": "TBK1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1227/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1227/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1227/?format=api" } } ] }