Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/STAR/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "459",
            "attributes": {
                "gene_relationship": [
                    "Indirectly interacting",
                    "Involved in the same disease",
                    "Affecting the same tissue",
                    "Relevant pathways for phenotype",
                    "Same pathway"
                ],
                "protein_interactions": [],
                "common_pathways": [
                    "Cushing syndrome",
                    "Cortisol synthesis and secretion",
                    "Cortisol synthesis and secretion"
                ],
                "genecomb_metascore": 2,
                "lastmodified": "2021-10-18T11:01:09.820790"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI667"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/459/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/459/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "NR5A1"
                        },
                        {
                            "type": "Gene",
                            "id": "STAR"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/459/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/459/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/459/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "953",
            "attributes": {
                "gene_relationship": [
                    "Relevant pathways for phenotype",
                    "Involved in the same disease"
                ],
                "protein_interactions": [],
                "common_pathways": [
                    "Metabolism of steroids",
                    "Ovarian steroidogenesis",
                    "Aldosterone synthesis and secretion",
                    "Metabolism of steroid hormones",
                    "Cushing syndrome",
                    "Metabolism of lipids",
                    "Metabolism",
                    "Cortisol synthesis and secretion",
                    "Pregnenolone biosynthesis"
                ],
                "genecomb_metascore": 2,
                "lastmodified": "2023-05-16T12:03:27.156182"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1372"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/953/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/953/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "CYP11A1"
                        },
                        {
                            "type": "Gene",
                            "id": "STAR"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/953/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/953/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/953/?format=api"
            }
        }
    ]
}