Gene Instance
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genes/PRKAR1A/?format=api
{ "data": { "type": "Gene", "id": "PRKAR1A", "attributes": { "go_molecular_function": [ "['cAMP-dependent protein kinase inhibitor activity', 'cAMP-dependent protein kinase regulator activity', 'protein domain specific binding', 'protein binding', 'protein kinase A catalytic subunit binding', 'ubiquitin protein ligase binding', 'cAMP binding']" ], "pathway_id": [ "kegg_path:hsa04910", "kegg_path:hsa04910", "R-HSA-109582", "R-HSA-111885", "R-HSA-111931", "R-HSA-111933", "R-HSA-111996", "R-HSA-111997", "R-HSA-112040", "R-HSA-112043", "R-HSA-112314", "R-HSA-112315", "R-HSA-112316", "R-HSA-1430728", "R-HSA-1489509", "R-HSA-162582", "R-HSA-163359", "R-HSA-163615", "R-HSA-163685", "R-HSA-1643685", "R-HSA-164378", "R-HSA-180024", "R-HSA-372790", "R-HSA-381676", "R-HSA-382551", "R-HSA-388396", "R-HSA-418594", "R-HSA-422356", "R-HSA-432040", "R-HSA-438064", "R-HSA-442720", "R-HSA-442755", "R-HSA-445717", "R-HSA-5358351", "R-HSA-5610787", "R-HSA-5663205", "R-HSA-9006925", "R-HSA-9658195", "R-HSA-9660821", "R-HSA-9662851", "R-HSA-9664323", "R-HSA-9664433", "R-HSA-983231" ], "essential_gene": "Essential", "status": null, "uniprot_acc": "P10644", "ensembl_id": "None", "entrez_id": "ENSG00000108946", "chromosome_number": "17" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3335" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PRKAR1A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PRKAR1A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1125" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PRKAR1A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PRKAR1A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PRKAR1A/?format=api" } }, "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "lastmodified": "2023-05-16T12:02:33.709315", "status": "CU", "curator": null, "submitter": "cnachteg" } }