Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/NPHP1/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "138", "attributes": { "gene_relationship": [ "Directly interacting", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway" ], "protein_interactions": [ "(NPHP1, NPHP3)" ], "common_pathways": [ "Cilium Assembly", "Organelle biogenesis and maintenance" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:52.008639" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI211" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/138/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/138/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "NPHP1" }, { "type": "Gene", "id": "NPHP3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/138/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/138/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/138/?format=api" } }, { "type": "GeneCombination", "id": "422", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Cilium Assembly", "Organelle biogenesis and maintenance" ], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:01:08.091955" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI616" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/422/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/422/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS2" }, { "type": "Gene", "id": "NPHP1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/422/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/422/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/422/?format=api" } }, { "type": "GeneCombination", "id": "423", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(BBS1, BBS4)", "(BBS1, BBS5)", "(BBS1, BBS7)", "(BBS4, BBS5)", "(BBS4, BBS7)", "(BBS5, BBS7)" ], "common_pathways": [ "Cilium Assembly", "Organelle biogenesis and maintenance", "Cargo trafficking to the periciliary membrane", "BBSome-mediated cargo-targeting to cilium", "Cargo trafficking to the periciliary membrane" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:08.160738" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI617" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/423/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/423/combinations/?format=api" } }, "genes": { "meta": { "count": 5 }, "data": [ { "type": "Gene", "id": "BBS1" }, { "type": "Gene", "id": "BBS4" }, { "type": "Gene", "id": "BBS5" }, { "type": "Gene", "id": "BBS7" }, { "type": "Gene", "id": "NPHP1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/423/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/423/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/423/?format=api" } }, { "type": "GeneCombination", "id": "426", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(BBS7, CEP290)" ], "common_pathways": [ "Cilium Assembly", "Organelle biogenesis and maintenance" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:08.338075" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI622" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/426/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/426/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS7" }, { "type": "Gene", "id": "CEP290" }, { "type": "Gene", "id": "NPHP1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/426/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/426/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/426/?format=api" } }, { "type": "GeneCombination", "id": "427", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:08.373498" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI623" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/427/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/427/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS10" }, { "type": "Gene", "id": "NPHP1" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/427/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/427/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/427/?format=api" } } ] }