Variant List
This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database
GET /api/genes/MKKS/variants/?format=api
{ "data": [ { "type": "SmallVariant", "id": "125", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 0.943362, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 10393457, "genomic_position_hg38": 10412809, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:41.263571", "ref_allele": "A", "alt_allele": "G", "cdna_change": null, "protein_change": "p.Ser236Pro", "transcript_id": null, "dbsnp_id": "NA", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI063" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/125/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/125/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/125/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/125/gene/?format=api" }, "data": { "type": "Gene", "id": "MKKS" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/125/?format=api" } }, { "type": "SmallVariant", "id": "130", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 2.215548, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 10393190, "genomic_position_hg38": 10412542, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:41.287709", "ref_allele": "T", "alt_allele": "G", "cdna_change": null, "protein_change": "p.Thr325Pro", "transcript_id": null, "dbsnp_id": "rs137853156", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI066" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/130/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/130/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/130/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/130/gene/?format=api" }, "data": { "type": "Gene", "id": "MKKS" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/130/?format=api" } }, { "type": "SmallVariant", "id": "133", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": null, "pp2_hvar_prediction": null, "cadd_prediction": 4.825142, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 10393721, "genomic_position_hg38": 10413073, "chromosome": "20", "annotation_flag": "manually_corrected", "lastmodified": "2023-06-06T16:57:41.305500", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.442C>T", "protein_change": "p.Gln148Ter", "transcript_id": "NM_170784.3", "dbsnp_id": "rs137853154", "variant_effect": "nonsense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI067" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/133/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/133/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/133/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/133/gene/?format=api" }, "data": { "type": "Gene", "id": "MKKS" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/133/?format=api" } }, { "type": "SmallVariant", "id": "172", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0018, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0029, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.007, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.00521, "gnomad_AFR_maf": 0.001358, "gnomad_AMR_maf": 0.00185, "gnomad_ASJ_maf": 0.001093, "gnomad_EAS_maf": 5.437e-05, "gnomad_FIN_maf": 0.004157, "gnomad_NFE_maf": 0.00969, "gnomad_OTH_maf": 0.003436, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": 0.001816, "ESP_EA_maf": 0.005814 }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Possibly Damaging", "cadd_prediction": 3.840462, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 10393439, "genomic_position_hg38": 10412791, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:41.531136", "ref_allele": "C", "alt_allele": "A", "cdna_change": "c.724G>T", "protein_change": "p.Ala242Ser", "transcript_id": "NM_018848.3", "dbsnp_id": "rs74315394", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 10 }, "data": [ { "type": "Combination", "id": "OLI085" }, { "type": "Combination", "id": "OLI170" }, { "type": "Combination", "id": "OLI171" }, { "type": "Combination", "id": "OLI177" }, { "type": "Combination", "id": "OLI225" }, { "type": "Combination", "id": "OLI614" }, { "type": "Combination", "id": "OLI1436" }, { "type": "Combination", "id": "OLI1437" }, { "type": "Combination", "id": "OLI084" }, { "type": "Combination", "id": "OLI1435" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/172/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/172/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/172/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/172/gene/?format=api" }, "data": { "type": "Gene", "id": "MKKS" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/172/?format=api" } }, { "type": "SmallVariant", "id": "178", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0108, "KGP_genomes_AFR_maf": 0.0393, "KGP_genomes_AMR_maf": 0.0029, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.002804, "gnomad_AFR_maf": 0.04011, "gnomad_AMR_maf": 0.001244, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 5.276e-05, "gnomad_OTH_maf": 0.0004889, "gnomad_SAS_maf": 3.266e-05, "ESP_AA_maf": 0.03768, "ESP_EA_maf": 0.0001163 }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 0.686827, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 10386146, "genomic_position_hg38": 10405498, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:41.568484", "ref_allele": "C", "alt_allele": "T", "cdna_change": null, "protein_change": "p.Ala488Thr", "transcript_id": null, "dbsnp_id": "rs61734546", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI087" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/178/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/178/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/178/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/178/gene/?format=api" }, "data": { "type": "Gene", "id": "MKKS" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/178/?format=api" } }, { "type": "SmallVariant", "id": "293", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0002, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.001, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.0001075, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.002283, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 2.641e-05, "gnomad_OTH_maf": 0.0001633, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.0001163 }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": -0.125061, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 10393237, "genomic_position_hg38": 10412589, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.249875", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.926G>A", "protein_change": "p.Arg309His", "transcript_id": "NM_018848.3", "dbsnp_id": "rs199939179", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI143" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/293/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/293/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/293/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/293/gene/?format=api" }, "data": { "type": "Gene", "id": "MKKS" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/293/?format=api" } }, { "type": "SmallVariant", "id": "348", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0022, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0043, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.004, "KGP_genomes_SAS_maf": 0.0041, "gnomad_maf": 0.004218, "gnomad_AFR_maf": 0.0001231, "gnomad_AMR_maf": 0.002604, "gnomad_ASJ_maf": 0.002781, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.006937, "gnomad_NFE_maf": 0.00504, "gnomad_OTH_maf": 0.006213, "gnomad_SAS_maf": 0.005852, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.004535 }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": -0.072919, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 10389422, "genomic_position_hg38": 10408774, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.564071", "ref_allele": "T", "alt_allele": "C", "cdna_change": "c.1015A>G", "protein_change": "p.Ile339Val", "transcript_id": "NM_018848.3", "dbsnp_id": "rs137853909", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI175" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/348/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/348/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/348/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/348/gene/?format=api" }, "data": { "type": "Gene", "id": "MKKS" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/348/?format=api" } }, { "type": "SmallVariant", "id": "435", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 6.772e-05, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0001322, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 6.536e-05, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.0002326 }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.7613, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 10394053, "genomic_position_hg38": 10413405, "chromosome": "20", "annotation_flag": "manually_attributed", "lastmodified": "2023-06-06T16:57:43.079016", "ref_allele": "T", "alt_allele": "C", "cdna_change": "c.110A>G", "protein_change": "p.Tyr37Cys", "transcript_id": "NM_170784.3", "dbsnp_id": "rs74315396", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI224" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/435/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/435/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/435/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/435/gene/?format=api" }, "data": { "type": "Gene", "id": "MKKS" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/435/?format=api" } }, { "type": "SmallVariant", "id": "437", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 4.053117, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 10386112, "genomic_position_hg38": 10405464, "chromosome": "20", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:43.085114", "ref_allele": "C", "alt_allele": "G", "cdna_change": null, "protein_change": "p.Cys499Ser", "transcript_id": null, "dbsnp_id": "rs281797259", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI226" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/437/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/437/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/437/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/437/gene/?format=api" }, "data": { "type": "Gene", "id": "MKKS" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/437/?format=api" } }, { "type": "SmallVariant", "id": "2437", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0108, "KGP_genomes_AFR_maf": 0.0393, "KGP_genomes_AMR_maf": 0.0029, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.002804, "gnomad_AFR_maf": 0.04011, "gnomad_AMR_maf": 0.001244, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 5.276e-05, "gnomad_OTH_maf": 0.0004889, "gnomad_SAS_maf": 3.266e-05, "ESP_AA_maf": 0.03768, "ESP_EA_maf": 0.0001163 }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 0.686827, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 10386146, "genomic_position_hg38": 10405498, "chromosome": "20", "annotation_flag": null, "lastmodified": "2023-06-06T16:57:55.254750", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.1462G>A", "protein_change": "p.Ala488Thr", "transcript_id": "NM_170784.3", "dbsnp_id": "rs61734546", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1131" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/2437/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/2437/combinations/?format=api" } }, 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