Variant List
This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database
GET /api/genes/LRP5/variants/?format=api
{ "data": [ { "type": "SmallVariant", "id": "362", "attributes": { "frequencies": { "KGP_genomes_maf": 0.003, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.0149, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.0006397, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.007942, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0, "gnomad_OTH_maf": 0.000654, "gnomad_SAS_maf": 0.0003266, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 2.540195, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 68192694, "genomic_position_hg38": 68425226, "chromosome": "11", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:42.636721", "ref_allele": "A", "alt_allele": "G", "cdna_change": "c.3361A>G", "protein_change": "p.Asn1121Asp", "transcript_id": "NM_002335.3", "dbsnp_id": "rs80358317", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 4 }, "data": [ { "type": "Combination", "id": "OLI185" }, { "type": "Combination", "id": "OLI303" }, { "type": "Combination", "id": "OLI305" }, { "type": "Combination", "id": "OLI315" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/362/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/362/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/362/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/362/gene/?format=api" }, "data": { "type": "Gene", "id": "LRP5" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/362/?format=api" } }, { "type": "SmallVariant", "id": "589", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 4.036e-06, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 5.488e-05, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.844651, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68201228, "genomic_position_hg38": 68433760, "chromosome": "11", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:43.952326", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.3922G>A", "protein_change": "p.Gly1308Ser", "transcript_id": "NM_002335.3", "dbsnp_id": "rs764890075", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI304" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/589/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/589/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/589/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/589/gene/?format=api" }, "data": { "type": "Gene", "id": "LRP5" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/589/?format=api" } }, { "type": "SmallVariant", "id": "592", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0002, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0, "KGP_genomes_EAS_maf": 0.001, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 3.99e-06, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 5.44e-05, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 0.0, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Benign", "cadd_prediction": 2.334672, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 68193556, "genomic_position_hg38": 68426088, "chromosome": "11", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:43.968689", "ref_allele": "G", "alt_allele": "A", "cdna_change": "c.3538G>A", "protein_change": "p.Val1180Met", "transcript_id": "NM_002335.3", "dbsnp_id": "rs186535471", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI306" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/592/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/592/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/592/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/592/gene/?format=api" }, "data": { "type": "Gene", "id": "LRP5" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/592/?format=api" } }, { "type": "SmallVariant", "id": "594", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 3.881682, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68181231, "genomic_position_hg38": 68413763, "chromosome": "11", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:43.979036", "ref_allele": "T", "alt_allele": "C", "cdna_change": "c.2578T>C", "protein_change": "p.Trp860Arg", "transcript_id": "NM_002335.3", "dbsnp_id": "NA", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI307" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/594/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/594/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/594/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/594/gene/?format=api" }, "data": { "type": "Gene", "id": "LRP5" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/594/?format=api" } }, { "type": "SmallVariant", "id": "596", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": null, "pp2_hvar_prediction": null, "cadd_prediction": 0.549758, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 68177378, "genomic_position_hg38": 68409910, "chromosome": "11", "annotation_flag": "automatically_attributed_and_verified", "lastmodified": "2023-06-06T16:57:43.989516", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.2092-4C>T", "protein_change": null, "transcript_id": "NM_002335.3", "dbsnp_id": "NA", "variant_effect": "splicing" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI308" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/596/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/596/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/596/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/596/gene/?format=api" }, "data": { "type": "Gene", "id": "LRP5" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/596/?format=api" } }, { "type": "SmallVariant", "id": "598", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 1.194e-05, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0001087, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 8.797e-06, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Benign", "cadd_prediction": 1.006718, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 68204440, "genomic_position_hg38": 68436972, "chromosome": "11", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:43.999773", "ref_allele": "A", "alt_allele": "G", "cdna_change": "c.4084A>G", "protein_change": "p.Ile1362Val", "transcript_id": "NM_002335.3", "dbsnp_id": "rs767699531", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI309" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/598/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/598/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/598/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/598/gene/?format=api" }, "data": { "type": "Gene", "id": "LRP5" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/598/?format=api" } }, { "type": "SmallVariant", "id": "600", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": null, "gnomad_AFR_maf": null, "gnomad_AMR_maf": null, "gnomad_ASJ_maf": null, "gnomad_EAS_maf": null, "gnomad_FIN_maf": null, "gnomad_NFE_maf": null, "gnomad_OTH_maf": null, "gnomad_SAS_maf": null, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Tolerated", "pp2_hvar_prediction": "Possibly Damaging", "cadd_prediction": 2.944007, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 68204405, "genomic_position_hg38": 68436937, "chromosome": "11", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:44.009721", "ref_allele": "T", "alt_allele": "A", "cdna_change": "c.2306T>A", "protein_change": "p.Leu769His", "transcript_id": "NM_001291902.1", "dbsnp_id": "rs531205284", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI310" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/600/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/600/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/600/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/600/gene/?format=api" }, "data": { "type": "Gene", "id": "LRP5" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/600/?format=api" } }, { "type": "SmallVariant", "id": "602", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 3.183e-05, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 5.437e-05, "gnomad_FIN_maf": 0.0, "gnomad_NFE_maf": 6.157e-05, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": 0.0, "ESP_EA_maf": 0.0002329 }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 4.097967, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68213932, "genomic_position_hg38": 68446464, "chromosome": "11", "annotation_flag": "automatically_attributed", "lastmodified": "2023-06-06T16:57:44.019738", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.4517C>T", "protein_change": "p.Thr1506Met", "transcript_id": "NM_002335.3", "dbsnp_id": "rs371173423", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI311" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/602/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/602/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/602/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/602/gene/?format=api" }, "data": { "type": "Gene", "id": "LRP5" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/602/?format=api" } }, { "type": "SmallVariant", "id": "898", "attributes": { "frequencies": { "KGP_genomes_maf": null, "KGP_genomes_AFR_maf": null, "KGP_genomes_AMR_maf": null, "KGP_genomes_EAS_maf": null, "KGP_genomes_EUR_maf": null, "KGP_genomes_SAS_maf": null, "gnomad_maf": 1.998e-50, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 4.633e-05, "gnomad_NFE_maf": 3.541e-05, "gnomad_OTH_maf": 0.0, "gnomad_SAS_maf": 0.0, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Benign", "cadd_prediction": 3.346486, "mutationtaster_prediction": "Disease causing" }, "status": "CU", "genomic_position_hg19": 68154098, "genomic_position_hg38": 68386630, "chromosome": "11", "annotation_flag": "manually_attributed", "lastmodified": "2023-06-06T16:57:45.890775", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.1330C>T", "protein_change": "p.Arg444Cys", "transcript_id": "NM_002335.4", "dbsnp_id": "rs80358308", "variant_effect": "missense" }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI419" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/898/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/898/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/898/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/898/gene/?format=api" }, "data": { "type": "Gene", "id": "LRP5" } } }, "links": { "self": "https://olida.ibsquare.be/api/variants/898/?format=api" } }, { "type": "SmallVariant", "id": "2318", "attributes": { "frequencies": { "KGP_genomes_maf": 0.0002, "KGP_genomes_AFR_maf": 0.0, "KGP_genomes_AMR_maf": 0.0014, "KGP_genomes_EAS_maf": 0.0, "KGP_genomes_EUR_maf": 0.0, "KGP_genomes_SAS_maf": 0.0, "gnomad_maf": 0.0003899, "gnomad_AFR_maf": 0.0, "gnomad_AMR_maf": 0.0001735, "gnomad_ASJ_maf": 0.0, "gnomad_EAS_maf": 0.0, "gnomad_FIN_maf": 0.002454, "gnomad_NFE_maf": 0.0002903, "gnomad_OTH_maf": 0.0008146, "gnomad_SAS_maf": 3.266e-05, "ESP_AA_maf": null, "ESP_EA_maf": null }, "predictions": { "sift_prediction": "Deleterious", "pp2_hvar_prediction": "Damaging", "cadd_prediction": 4.157421, "mutationtaster_prediction": "Polymorphism" }, "status": "CU", "genomic_position_hg19": 68213926, "genomic_position_hg38": 68446458, "chromosome": "11", "annotation_flag": null, "lastmodified": "2023-06-06T16:57:54.540327", "ref_allele": "C", "alt_allele": "T", "cdna_change": "c.4511C>T", "protein_change": "p.Pro1504Leu", "transcript_id": null, "dbsnp_id": "NA", "variant_effect": null }, "relationships": { "in_combination": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1059" } ], "links": { "self": "https://olida.ibsquare.be/api/variants/2318/relationships/in_combination?format=api", "related": "https://olida.ibsquare.be/api/variants/2318/combinations/?format=api" } }, "gene_name": { "links": { "self": "https://olida.ibsquare.be/api/variants/2318/relationships/gene_name?format=api", "related": "https://olida.ibsquare.be/api/variants/2318/gene/?format=api" }, "data": { "type": "Gene", "id": "LRP5" } } }, "links": { 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