Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/FGF17/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "252",
            "attributes": {
                "gene_relationship": [
                    "Directly interacting",
                    "Involved in the same disease",
                    "Relevant pathways for phenotype",
                    "Same pathway",
                    "Co-expression"
                ],
                "protein_interactions": [
                    "(FGF17, FGFR1)"
                ],
                "common_pathways": [
                    "Ras signaling pathway",
                    "Breast cancer",
                    "Melanoma",
                    "Calcium signaling pathway",
                    "Pathways in cancer",
                    "Rap1 signaling pathway",
                    "PI3K-Akt signaling pathway"
                ],
                "genecomb_metascore": 2,
                "lastmodified": "2021-10-18T11:00:58.487886"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI367"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/252/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/252/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 4
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "FGF17"
                        },
                        {
                            "type": "Gene",
                            "id": "FGFR1"
                        },
                        {
                            "type": "Gene",
                            "id": "FLRT3"
                        },
                        {
                            "type": "Gene",
                            "id": "HS6ST1"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/252/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/252/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/252/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "945",
            "attributes": {
                "gene_relationship": [
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 1,
                "lastmodified": "2023-05-16T12:03:27.100734"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1347"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/945/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/945/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "CHD7"
                        },
                        {
                            "type": "Gene",
                            "id": "FGF17"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/945/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/945/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/945/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1164",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Relevant pathways for phenotype",
                    "Same pathway"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 2,
                "lastmodified": "2024-02-29T15:02:21.643159"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1650"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1164/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1164/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "FGF17"
                        },
                        {
                            "type": "Gene",
                            "id": "IL17RD"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1164/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1164/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1164/?format=api"
            }
        }
    ]
}