Gene Instance
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genes/EGFR/?format=api
{ "data": { "type": "Gene", "id": "EGFR", "attributes": { "go_molecular_function": [ "['protein phosphatase binding', 'MAP kinase kinase kinase activity', 'transmembrane signaling receptor activity', 'kinase binding', 'double-stranded DNA binding', 'protein binding', 'virus receptor activity', 'identical protein binding', 'nitric-oxide synthase regulator activity', 'protein tyrosine kinase activity', 'actin filament binding', 'epidermal growth factor-activated receptor activity', 'chromatin binding', 'ATPase binding', 'ATP binding', 'cadherin binding', 'ubiquitin protein ligase binding', 'epidermal growth factor binding', 'enzyme binding', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa01522", "kegg_path:hsa04010", "kegg_path:hsa04012", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04066", "kegg_path:hsa04068", "kegg_path:hsa04072", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04520", "kegg_path:hsa04540", "kegg_path:hsa04630", "kegg_path:hsa04810", "kegg_path:hsa04912", "kegg_path:hsa04915", "kegg_path:hsa04921", "kegg_path:hsa04926", "kegg_path:hsa04928", "kegg_path:hsa04934", "kegg_path:hsa05120", "kegg_path:hsa05131", "kegg_path:hsa05160", "kegg_path:hsa05163", "kegg_path:hsa05165", "kegg_path:hsa05171", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa05210", "kegg_path:hsa05212", "kegg_path:hsa05213", "kegg_path:hsa05214", "kegg_path:hsa05215", "kegg_path:hsa05218", "kegg_path:hsa05219", "kegg_path:hsa05223", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05226", "kegg_path:hsa05230", "kegg_path:hsa05231", "kegg_path:hsa05235", "R-HSA-1227986", "R-HSA-1227990", "R-HSA-1236382", "R-HSA-1236394", "R-HSA-1250196", "R-HSA-1251932", "R-HSA-1257604", "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-1643713", "R-HSA-177929", "R-HSA-179812", "R-HSA-180292", "R-HSA-180336", "R-HSA-182971", "R-HSA-1963640", "R-HSA-1963642", "R-HSA-199418", "R-HSA-199991", "R-HSA-212436", "R-HSA-212718", "R-HSA-2179392", "R-HSA-2219528", "R-HSA-2219530", "R-HSA-372790", "R-HSA-373760", "R-HSA-388396", "R-HSA-416476", "R-HSA-422475", "R-HSA-445144", "R-HSA-5637810", "R-HSA-5637812", "R-HSA-5637815", "R-HSA-5638302", "R-HSA-5638303", "R-HSA-5653656", "R-HSA-5663202", "R-HSA-5663205", "R-HSA-5673001", "R-HSA-5683057", "R-HSA-5684996", "R-HSA-6785631", "R-HSA-6811558", "R-HSA-73857", "R-HSA-74160", "R-HSA-881907", "R-HSA-8847993", "R-HSA-8848021", "R-HSA-8856825", "R-HSA-8856828", "R-HSA-8857538", "R-HSA-8863795", "R-HSA-8864260", "R-HSA-8866910", "R-HSA-8939211", "R-HSA-9006925", "R-HSA-9006927", "R-HSA-9006931", "R-HSA-9006934", "R-HSA-9009391", "R-HSA-9012852", "R-HSA-9013507", "R-HSA-9609646", "R-HSA-9609690", "R-HSA-9634638", "R-HSA-9664565", "R-HSA-9665348", "R-HSA-9665686", "R-HSA-9675108", "kegg_path:hsa01521", "kegg_path:hsa01522", "kegg_path:hsa04010", "kegg_path:hsa04012", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04066", "kegg_path:hsa04068", "kegg_path:hsa04072", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04520", "kegg_path:hsa04540", "kegg_path:hsa04630", "kegg_path:hsa04810", "kegg_path:hsa04912", "kegg_path:hsa04915", "kegg_path:hsa04921", "kegg_path:hsa04926", "kegg_path:hsa04928", "kegg_path:hsa04934", "kegg_path:hsa05120", "kegg_path:hsa05131", "kegg_path:hsa05160", "kegg_path:hsa05163", "kegg_path:hsa05165", "kegg_path:hsa05171", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa05210", "kegg_path:hsa05212", "kegg_path:hsa05213", "kegg_path:hsa05214", "kegg_path:hsa05215", "kegg_path:hsa05218", "kegg_path:hsa05219", "kegg_path:hsa05223", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05226", "kegg_path:hsa05230", "kegg_path:hsa05231", "kegg_path:hsa05235" ], "essential_gene": "Essential", "status": null, "uniprot_acc": "P00533", "ensembl_id": "None", "entrez_id": "ENSG00000146648", "chromosome_number": "7" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1155" }, { "type": "SmallVariant", "id": "1886" }, { "type": "SmallVariant", "id": "1903" }, { "type": "SmallVariant", "id": "2613" }, { "type": "SmallVariant", "id": "2624" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EGFR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EGFR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "370" }, { "type": "GeneCombination", "id": "628" }, { "type": "GeneCombination", "id": "638" }, { "type": "GeneCombination", "id": "640" }, { "type": "GeneCombination", "id": "648" }, { "type": "GeneCombination", "id": "650" }, { "type": "GeneCombination", "id": "664" }, { "type": "GeneCombination", "id": "872" }, { "type": "GeneCombination", "id": "867" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EGFR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EGFR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/EGFR/?format=api" } }, "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "lastmodified": "2021-10-18T11:00:44.516235", "status": "CU", "curator": null, "submitter": "cnachteg" } }