Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/COL4A5/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "28", "attributes": { "gene_relationship": [ "Relevant pathways for phenotype", "Involved in the same disease", "Similar function" ], "protein_interactions": [], "common_pathways": [ "Non-integrin membrane-ECM interactions", "Integrin cell surface interactions", "Collagen formation", "Anchoring fibril formation", "Axon guidance", "Extracellular matrix organization", "Degradation of the extracellular matrix", "Crosslinking of collagen fibrils", "Signal Transduction", "Relaxin signaling pathway", "Amoebiasis", "Laminin interactions", "Protein digestion and absorption", "ECM-receptor interaction", "Pathways in cancer", "Collagen chain trimerization", "NCAM signaling for neurite out-growth", "Small cell lung cancer", "Focal adhesion", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Signaling by Receptor Tyrosine Kinases", "PI3K-Akt signaling pathway", "Human papillomavirus infection", "Nervous system development", "Developmental Biology", "Collagen degradation", "AGE-RAGE signaling pathway in diabetic complications", "Signaling by PDGF", "ECM proteoglycans", "NCAM1 interactions" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:27.160444" }, "relationships": { "combination_set": { "meta": { "count": 11 }, "data": [ { "type": "Combination", "id": "OLI033" }, { "type": "Combination", "id": "OLI383" }, { "type": "Combination", "id": "OLI384" }, { "type": "Combination", "id": "OLI385" }, { "type": "Combination", "id": "OLI386" }, { "type": "Combination", "id": "OLI387" }, { "type": "Combination", "id": "OLI388" }, { "type": "Combination", "id": "OLI1373" }, { "type": "Combination", "id": "OLI1374" }, { "type": "Combination", "id": "OLI1645" }, { "type": "Combination", "id": "OLI1647" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/28/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/28/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "COL4A4" }, { "type": "Gene", "id": "COL4A5" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/28/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/28/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/28/?format=api" } }, { "type": "GeneCombination", "id": "99", "attributes": { "gene_relationship": [ "Same protein complex", "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway", "Monogenic experiments only", "Similar function" ], "protein_interactions": [], "common_pathways": [ "Anchoring fibril formation", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "Axon guidance", "Focal adhesion", "Assembly of collagen fibrils and other multimeric structures", "Laminin interactions", "Signaling by Receptor Tyrosine Kinases", "Signaling by PDGF", "ECM-receptor interaction", "Extracellular matrix organization", "AGE-RAGE signaling pathway in diabetic complications", "Protein digestion and absorption", "ECM proteoglycans", "Amoebiasis", "Developmental Biology", "NCAM signaling for neurite out-growth", "Nervous system development", "Collagen chain trimerization", "Degradation of the extracellular matrix", "Pathways in cancer", "Relaxin signaling pathway", "NCAM1 interactions", "Small cell lung cancer", "Crosslinking of collagen fibrils", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Human papillomavirus infection", "PI3K-Akt signaling pathway", "Signal Transduction" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:49.728395" }, "relationships": { "combination_set": { "meta": { "count": 5 }, "data": [ { "type": "Combination", "id": "OLI133" }, { "type": "Combination", "id": "OLI156" }, { "type": "Combination", "id": "OLI516" }, { "type": "Combination", "id": "OLI1644" }, { "type": "Combination", "id": "OLI1646" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/99/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/99/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "COL4A3" }, { "type": "Gene", "id": "COL4A5" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/99/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/99/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/99/?format=api" } }, { "type": "GeneCombination", "id": "350", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [ "ECM-receptor interaction", "Extracellular matrix organization", "Small cell lung cancer", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Focal adhesion", "Laminin interactions", "Degradation of the extracellular matrix", "Pathways in cancer", "Human papillomavirus infection", "Signaling by Receptor Tyrosine Kinases", "Amoebiasis", "PI3K-Akt signaling pathway", "Signal Transduction" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:03.550311" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI504" }, { "type": "Combination", "id": "OLI916" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/350/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/350/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "COL4A5" }, { "type": "Gene", "id": "LAMA5" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/350/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/350/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/350/?format=api" } } ] }