Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genes/CEP290/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "159", "attributes": { "gene_relationship": [ "Same pathway", "Monogenic experiments only" ], "protein_interactions": [], "common_pathways": [ "Centrosome maturation", "G2/M Transition", "Anchoring of the basal body to the plasma membrane", "M Phase", "Cilium Assembly", "Mitotic Prometaphase", "Mitotic", "Regulation of PLK1 Activity at G2/M Transition", "Cell Cycle", "AURKA Activation by TPX2", "Organelle biogenesis and maintenance", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Mitotic G2-G2/M phases", "Loss of Nlp from mitotic centrosomes", "Cell Cycle" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:53.115223" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI244" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/159/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/159/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CEP290" }, { "type": "Gene", "id": "CEP41" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/159/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/159/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/159/?format=api" } }, { "type": "GeneCombination", "id": "213", "attributes": { "gene_relationship": [ "Involved in the same disease", "Indirectly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(BBS1, CEP290)" ], "common_pathways": [ "Cilium Assembly", "Cargo trafficking to the periciliary membrane", "Organelle biogenesis and maintenance", "BBSome-mediated cargo-targeting to cilium" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:55.553158" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI324" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/213/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/213/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS1" }, { "type": "Gene", "id": "BBS10" }, { "type": "Gene", "id": "CEP290" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/213/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/213/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/213/?format=api" } }, { "type": "GeneCombination", "id": "426", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(BBS7, CEP290)" ], "common_pathways": [ "Cilium Assembly", "Organelle biogenesis and maintenance" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:08.338075" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI622" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/426/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/426/combinations/?format=api" } }, "genes": { "meta": { "count": 3 }, "data": [ { "type": "Gene", "id": "BBS7" }, { "type": "Gene", "id": "CEP290" }, { "type": "Gene", "id": "NPHP1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/426/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/426/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/426/?format=api" } }, { "type": "GeneCombination", "id": "834", "attributes": { "gene_relationship": [ "Same protein complex", "Directly interacting", "Colocalization", "Same pathway", "Similar function", "Relevant pathways for phenotype" ], "protein_interactions": [ "(CEP290, BBS4)", "(CEP290, BBS1)", "(CEP290, TTC8)", "(BBS4, BBS1)", "(BBS4, TTC8)", "(BBS1, TTC8)" ], "common_pathways": [ "Organelle biogenesis and maintenance", "Cilium Assembly" ], "genecomb_metascore": 2, "lastmodified": "2024-03-01T14:46:41.795324" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1146" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/834/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/834/combinations/?format=api" } }, "genes": { "meta": { "count": 5 }, "data": [ { "type": "Gene", "id": "BBS1" }, { "type": "Gene", "id": "BBS4" }, { "type": "Gene", "id": "CEP290" }, { "type": "Gene", "id": "MKS1" }, { "type": "Gene", "id": "TTC8" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/834/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/834/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/834/?format=api" } }, { "type": "GeneCombination", "id": "1021", "attributes": { "gene_relationship": [], "protein_interactions": [ "(BBS9, CEP290)" ], "common_pathways": [ "Organelle biogenesis and maintenance", "Cilium Assembly" ], "genecomb_metascore": 2, "lastmodified": "2023-05-16T12:03:27.551098" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI1452" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1021/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1021/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BBS9" }, { "type": "Gene", "id": "CEP290" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1021/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1021/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1021/?format=api" } } ] }