Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genes/BMP15/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "67",
            "attributes": {
                "gene_relationship": [
                    "Monogenic experiments only",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 1,
                "lastmodified": "2021-10-18T11:00:48.267056"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI092"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/67/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/67/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "BMP15"
                        },
                        {
                            "type": "Gene",
                            "id": "SMC1B"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/67/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/67/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/67/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "70",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Monogenic experiments only",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [],
                "genecomb_metascore": 1,
                "lastmodified": "2021-10-18T11:00:48.381370"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI095"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/70/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/70/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "BMP15"
                        },
                        {
                            "type": "Gene",
                            "id": "NOBOX"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/70/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/70/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/70/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "780",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Directly interacting",
                    "Same pathway",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [
                    "(BMP15, GDF9)"
                ],
                "common_pathways": [
                    "Cytokine-cytokine receptor interaction"
                ],
                "genecomb_metascore": 2,
                "lastmodified": "2024-03-01T14:48:46.746097"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1060"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/780/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/780/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "BMP15"
                        },
                        {
                            "type": "Gene",
                            "id": "GDF9"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/780/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/780/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/780/?format=api"
            }
        },
        {
            "type": "GeneCombination",
            "id": "1233",
            "attributes": {
                "gene_relationship": [
                    "Involved in the same disease",
                    "Relevant pathways for phenotype"
                ],
                "protein_interactions": [],
                "common_pathways": [
                    "Post-translational protein modification",
                    "Metabolism of proteins"
                ],
                "genecomb_metascore": 1,
                "lastmodified": "2024-02-29T15:02:23.069791"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1725"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1233/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1233/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "BMP15"
                        },
                        {
                            "type": "Gene",
                            "id": "FOXL2"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/1233/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/1233/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/1233/?format=api"
            }
        }
    ]
}