Combination List
This API endpoint handles listing (/combinations) and retrieval (/combinations/{combination_pk}/) of oligogenic combinations from the database
GET /api/diseases/174590/combinations/?format=api
{ "data": [ { "type": "Combination", "id": "OLI018", "attributes": { "scores": { "familial_evidence": 2, "statistical_evidence_manual": 1, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 1, "functional_gene_evidence_manual_harmonized": 1, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 1, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 1, "functional_final_metascore": 1, "final_manual": 1, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "True Digenic", "status": "CU", "effect_predicted": false, "ethnicity": "European/Caucasian", "lastmodified": "2021-11-16T17:59:37.618903" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "174590" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI018/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI018/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "35" }, { "type": "SmallVariant", "id": "36" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI018/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI018/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "658" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI018/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI018/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI018/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI018/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "14" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI018/?format=api" } }, { "type": "Combination", "id": "OLI019", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 1, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 1, "functional_gene_evidence_manual_harmonized": 1, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 1, "functional_variant_evidence_manual": 2, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 2, "functional_final_manual": 2, "functional_final_metascore": 2, "final_manual": 1, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "European/Caucasian", "lastmodified": "2021-11-16T17:59:37.633374" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "174590" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI019/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI019/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "37" }, { "type": "SmallVariant", "id": "38" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI019/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI019/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "658" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI019/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI019/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI019/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI019/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "15" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI019/?format=api" } }, { "type": "Combination", "id": "OLI020", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 1, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 1, "functional_gene_evidence_manual_harmonized": 1, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 1, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 1, "functional_final_metascore": 1, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "European/Caucasian", "lastmodified": "2021-11-16T17:59:37.649345" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "174590" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI020/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI020/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "39" }, { "type": "SmallVariant", "id": "40" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI020/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI020/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "658" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI020/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI020/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI020/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI020/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "16" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI020/?format=api" } }, { "type": "Combination", "id": "OLI650", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 0, "functional_gene_evidence_manual_harmonized": 0, "functional_gene_evidence_knowledge": 1, "functional_gene_evidence_metascore": 1, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 1, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "Unknown", "lastmodified": "2021-11-16T17:59:49.653561" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "174590" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI650/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI650/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1414" }, { "type": "SmallVariant", "id": "1415" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI650/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI650/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "815" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI650/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI650/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI650/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI650/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "444" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI650/?format=api" } }, { "type": "Combination", "id": "OLI651", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 0, "functional_gene_evidence_manual_harmonized": 0, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 0, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 0, "functional_variant_evidence_metascore": 0, "functional_final_manual": 0, "functional_final_metascore": 0, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "Unknown", "lastmodified": "2021-11-16T17:59:49.675415" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "174590" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI651/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI651/diseases/?format=api" } }, "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1414" }, { "type": "SmallVariant", "id": "1416" }, { "type": "SmallVariant", "id": "1417" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI651/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI651/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "815" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI651/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI651/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI651/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI651/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "445" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI651/?format=api" } }, { "type": "Combination", "id": "OLI652", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 0, "functional_gene_evidence_manual_harmonized": 0, "functional_gene_evidence_knowledge": 1, "functional_gene_evidence_metascore": 1, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 1, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "Unknown", "lastmodified": "2021-11-16T17:59:49.696818" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "174590" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI652/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI652/diseases/?format=api" } }, "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1418" }, { "type": "SmallVariant", "id": "1419" }, { "type": "SmallVariant", "id": "1420" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI652/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI652/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "815" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI652/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI652/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI652/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI652/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "446" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI652/?format=api" } }, { "type": "Combination", "id": "OLI653", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 0, "functional_gene_evidence_manual_harmonized": 0, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 0, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 0, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "Unknown", "lastmodified": "2021-11-16T17:59:49.712029" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "174590" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI653/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI653/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1421" }, { "type": "SmallVariant", "id": "1422" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI653/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI653/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "815" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI653/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI653/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI653/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI653/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "447" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI653/?format=api" } }, { "type": "Combination", "id": "OLI654", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 0, "functional_gene_evidence_manual_harmonized": 0, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 0, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 0, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "Unknown", "lastmodified": "2021-11-16T17:59:49.727972" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "174590" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI654/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI654/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1423" }, { "type": "SmallVariant", "id": "1424" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI654/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI654/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "815" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI654/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI654/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI654/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI654/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "448" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI654/?format=api" } }, { "type": "Combination", "id": "OLI1651", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 1, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 1, "functional_gene_evidence_manual_harmonized": 1, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 1, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 1, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "European/Caucasian", "lastmodified": "2024-02-29T15:02:26.626906" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "174590" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1651/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1651/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3471" }, { "type": "SmallVariant", "id": "3472" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1651/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1651/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "979" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1651/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1651/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1651/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1651/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "1165" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1651/?format=api" } }, { "type": "Combination", "id": "OLI1801", "attributes": { "scores": { "familial_evidence": 2, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 2, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 2, "functional_final_manual": 2, "functional_final_metascore": 2, "final_manual": 2, "final_metascore": 2 }, "omim_id": [], "oligogenic_effect": "Monogenic+Modifier", "status": "CU", "effect_predicted": false, "ethnicity": "Unknown", "lastmodified": "2024-02-29T15:02:38.171136" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "174590" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1801/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1801/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3767" }, { "type": "SmallVariant", "id": "3768" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1801/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1801/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "1006" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1801/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1801/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1801/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI1801/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "1276" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI1801/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 10 } }