This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database

GET /api/combinations/OLI761/variants/?format=api
HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "SmallVariant",
            "id": "1499",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0034,
                    "KGP_genomes_AFR_maf": 0.0,
                    "KGP_genomes_AMR_maf": 0.0101,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.0099,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.004665,
                    "gnomad_AFR_maf": 0.0008612,
                    "gnomad_AMR_maf": 0.003556,
                    "gnomad_ASJ_maf": 0.0002976,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.01238,
                    "gnomad_NFE_maf": 0.006357,
                    "gnomad_OTH_maf": 0.005708,
                    "gnomad_SAS_maf": 0.0002287,
                    "ESP_AA_maf": 0.001362,
                    "ESP_EA_maf": 0.006047
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Possibly Damaging",
                    "cadd_prediction": 4.171235,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 103002451,
                "genomic_position_hg38": 100240169,
                "chromosome": "9",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:49.532809",
                "ref_allele": "C",
                "alt_allele": "T",
                "cdna_change": "c.725C>T",
                "protein_change": "p.Ser242Leu",
                "transcript_id": "NM_014425.4",
                "dbsnp_id": "rs2491097",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 3
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI691"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI736"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI761"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1499/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1499/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1499/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1499/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "INVS"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1499/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1571",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.9964,
                    "KGP_genomes_AFR_maf": 0.0,
                    "KGP_genomes_AMR_maf": 0.0029,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.0109,
                    "KGP_genomes_SAS_maf": 0.0051,
                    "gnomad_maf": 0.005282,
                    "gnomad_AFR_maf": 0.001602,
                    "gnomad_AMR_maf": 0.001893,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 5.459e-05,
                    "gnomad_FIN_maf": 0.01072,
                    "gnomad_NFE_maf": 0.007704,
                    "gnomad_OTH_maf": 0.004939,
                    "gnomad_SAS_maf": 0.003152,
                    "ESP_AA_maf": 0.001641,
                    "ESP_EA_maf": 0.00739
                },
                "predictions": {
                    "sift_prediction": null,
                    "pp2_hvar_prediction": null,
                    "cadd_prediction": 4.321915,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 74702809,
                "genomic_position_hg38": 73837092,
                "chromosome": "4",
                "annotation_flag": "manually_corrected",
                "lastmodified": "2023-06-06T16:57:49.979026",
                "ref_allele": "G",
                "alt_allele": "GT",
                "cdna_change": "c.239dup",
                "protein_change": "p.Val81GlyfsTer44",
                "transcript_id": null,
                "dbsnp_id": "rs564244632",
                "variant_effect": "frameshift"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI716"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI761"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1571/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1571/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1571/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1571/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "CXCL6"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1571/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1686",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0012,
                    "KGP_genomes_AFR_maf": 0.0008,
                    "KGP_genomes_AMR_maf": 0.0,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.001,
                    "KGP_genomes_SAS_maf": 0.0041,
                    "gnomad_maf": 0.001391,
                    "gnomad_AFR_maf": 0.0001846,
                    "gnomad_AMR_maf": 0.0008095,
                    "gnomad_ASJ_maf": 0.0007938,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0001424,
                    "gnomad_NFE_maf": 0.001741,
                    "gnomad_OTH_maf": 0.001141,
                    "gnomad_SAS_maf": 0.003332,
                    "ESP_AA_maf": 0.0,
                    "ESP_EA_maf": 0.001279
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Damaging",
                    "cadd_prediction": 3.872045,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 46564053,
                "genomic_position_hg38": 46542503,
                "chromosome": "11",
                "annotation_flag": "automatically_attributed_and_verified",
                "lastmodified": "2023-06-06T16:57:50.706884",
                "ref_allele": "C",
                "alt_allele": "T",
                "cdna_change": "c.1244G>A",
                "protein_change": "p.Arg415His",
                "transcript_id": "NM_001267782.2",
                "dbsnp_id": "rs145466300",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI761"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1686/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1686/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1686/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1686/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "AMBRA1"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1686/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1687",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": null,
                    "KGP_genomes_AFR_maf": null,
                    "KGP_genomes_AMR_maf": null,
                    "KGP_genomes_EAS_maf": null,
                    "KGP_genomes_EUR_maf": null,
                    "KGP_genomes_SAS_maf": null,
                    "gnomad_maf": 5.17e-05,
                    "gnomad_AFR_maf": 6.152e-05,
                    "gnomad_AMR_maf": 0.0,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0,
                    "gnomad_NFE_maf": 0.0001055,
                    "gnomad_OTH_maf": 0.0,
                    "gnomad_SAS_maf": 0.0,
                    "ESP_AA_maf": 0.000227,
                    "ESP_EA_maf": 0.0001163
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Damaging",
                    "cadd_prediction": 3.978401,
                    "mutationtaster_prediction": "Disease causing"
                },
                "status": "CU",
                "genomic_position_hg19": 32878442,
                "genomic_position_hg38": 34290636,
                "chromosome": "20",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:50.713391",
                "ref_allele": "A",
                "alt_allele": "G",
                "cdna_change": "c.769T>C",
                "protein_change": "p.Tyr257His",
                "transcript_id": "NM_000687.3",
                "dbsnp_id": "rs140810436",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI761"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1687/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1687/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1687/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1687/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "AHCY"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1687/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1688",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": null,
                    "KGP_genomes_AFR_maf": null,
                    "KGP_genomes_AMR_maf": null,
                    "KGP_genomes_EAS_maf": null,
                    "KGP_genomes_EUR_maf": null,
                    "KGP_genomes_SAS_maf": null,
                    "gnomad_maf": 0.0002479,
                    "gnomad_AFR_maf": 6.185e-05,
                    "gnomad_AMR_maf": 0.0,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 9.247e-05,
                    "gnomad_NFE_maf": 0.0004974,
                    "gnomad_OTH_maf": 0.0003269,
                    "gnomad_SAS_maf": 3.267e-05,
                    "ESP_AA_maf": 0.0,
                    "ESP_EA_maf": 0.0009302
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Damaging",
                    "cadd_prediction": 3.006867,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 64142993,
                "genomic_position_hg38": 64157317,
                "chromosome": "3",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:50.719801",
                "ref_allele": "C",
                "alt_allele": "A",
                "cdna_change": "c.445G>T",
                "protein_change": "p.Ala149Ser",
                "transcript_id": "NM_198859.3",
                "dbsnp_id": "rs202025796",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI761"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1688/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1688/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1688/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1688/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "PRICKLE2"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1688/?format=api"
            }
        }
    ],
    "meta": {
        "database_name": "OLIgogenic diseases DAtabase (OLIDA)",
        "resource_url": "olida.ibsquare.be",
        "api_release_year": "2021",
        "api_developer": [
            [
                "Arnau Dillen",
                "arnau.dillen@ulb.ac.be"
            ],
            [
                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
            ]
        ],
        "api_version": "0.3",
        "api_maintainers": [
            [
                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
            ]
        ],
        "api_documentation": [
            "olida.ibsquare.be/api/swagger",
            "olida.ibsquare.be/api/redoc"
        ],
        "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.",
        "license": "CC Attribution-NonCommercial 4.0 International License",
        "ontologies": {
            "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO",
            "GENO": "http://purl.obolibrary.org/obo/geno.owl",
            "MI": "http://purl.obolibrary.org/obo/mi.owl",
            "NCIT": "http://purl.obolibrary.org/obo/ncit.owl",
            "OGI": "http://purl.obolibrary.org/obo/ogi.owl",
            "OGG": "http://purl.obolibrary.org/obo/ogg.owl"
        },
        "relevant_publications_doi": [
            "10.1093/nar/gkv1068",
            "10.1093/database/baac023"
        ],
        "Variant serializers": [
            "SmallVariantSerializer",
            "CopyNumberVariantSerializer"
        ],
        "size": 5
    }
}