This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database

GET /api/combinations/OLI647/variants/?format=api
HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "SmallVariant",
            "id": "1401",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": null,
                    "KGP_genomes_AFR_maf": null,
                    "KGP_genomes_AMR_maf": null,
                    "KGP_genomes_EAS_maf": null,
                    "KGP_genomes_EUR_maf": null,
                    "KGP_genomes_SAS_maf": null,
                    "gnomad_maf": 4.015e-06,
                    "gnomad_AFR_maf": 6.457e-05,
                    "gnomad_AMR_maf": 0.0,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0,
                    "gnomad_NFE_maf": 0.0,
                    "gnomad_OTH_maf": 0.0,
                    "gnomad_SAS_maf": 0.0,
                    "ESP_AA_maf": null,
                    "ESP_EA_maf": null
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 2.141453,
                    "mutationtaster_prediction": "Disease causing"
                },
                "status": "CU",
                "genomic_position_hg19": 237753154,
                "genomic_position_hg38": 237589854,
                "chromosome": "1",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.895020",
                "ref_allele": "T",
                "alt_allele": "A",
                "cdna_change": "c.3660T>A",
                "protein_change": "p.Asp1220Glu",
                "transcript_id": "NM_001035.2",
                "dbsnp_id": "rs1019112544",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI647"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1401/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1401/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1401/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1401/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "RYR2"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1401/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1402",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": null,
                    "KGP_genomes_AFR_maf": null,
                    "KGP_genomes_AMR_maf": null,
                    "KGP_genomes_EAS_maf": null,
                    "KGP_genomes_EUR_maf": null,
                    "KGP_genomes_SAS_maf": null,
                    "gnomad_maf": null,
                    "gnomad_AFR_maf": null,
                    "gnomad_AMR_maf": null,
                    "gnomad_ASJ_maf": null,
                    "gnomad_EAS_maf": null,
                    "gnomad_FIN_maf": null,
                    "gnomad_NFE_maf": null,
                    "gnomad_OTH_maf": null,
                    "gnomad_SAS_maf": null,
                    "ESP_AA_maf": null,
                    "ESP_EA_maf": null
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Damaging",
                    "cadd_prediction": 4.08511,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 228528584,
                "genomic_position_hg38": 228340883,
                "chromosome": "1",
                "annotation_flag": "manually_attributed",
                "lastmodified": "2023-06-06T16:57:48.901828",
                "ref_allele": "C",
                "alt_allele": "A",
                "cdna_change": "c.20563C>A",
                "protein_change": "p.Arg6855Ser",
                "transcript_id": "NM_001271223.2",
                "dbsnp_id": "NA",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI647"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1402/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1402/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1402/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1402/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "OBSCN"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1402/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1403",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.016,
                    "KGP_genomes_AFR_maf": 0.0598,
                    "KGP_genomes_AMR_maf": 0.0014,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.0,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.003685,
                    "gnomad_AFR_maf": 0.05377,
                    "gnomad_AMR_maf": 0.003424,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0,
                    "gnomad_NFE_maf": 0.0001395,
                    "gnomad_OTH_maf": 0.001939,
                    "gnomad_SAS_maf": 7.004e-05,
                    "ESP_AA_maf": 0.0438,
                    "ESP_EA_maf": 0.0002397
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 1.345989,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 2788901,
                "genomic_position_hg38": 2679735,
                "chromosome": "12",
                "annotation_flag": "automatically_attributed_and_verified",
                "lastmodified": "2023-06-06T16:57:48.908643",
                "ref_allele": "G",
                "alt_allele": "A",
                "cdna_change": "c.5383G>A",
                "protein_change": "p.Gly1795Arg",
                "transcript_id": "NM_001129840.2",
                "dbsnp_id": "rs111298509",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI647"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1403/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1403/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1403/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1403/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "CACNA1C"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1403/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1404",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0002,
                    "KGP_genomes_AFR_maf": 0.0,
                    "KGP_genomes_AMR_maf": 0.0,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.001,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 3.98e-05,
                    "gnomad_AFR_maf": 0.000123,
                    "gnomad_AMR_maf": 2.891e-05,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0,
                    "gnomad_NFE_maf": 6.164e-05,
                    "gnomad_OTH_maf": 0.0,
                    "gnomad_SAS_maf": 0.0,
                    "ESP_AA_maf": 0.000227,
                    "ESP_EA_maf": 0.0
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Damaging",
                    "cadd_prediction": 4.074119,
                    "mutationtaster_prediction": null
                },
                "status": "CU",
                "genomic_position_hg19": 28648084,
                "genomic_position_hg38": 31068118,
                "chromosome": "18",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.915608",
                "ref_allele": "G",
                "alt_allele": "A",
                "cdna_change": "c.2603C>T",
                "protein_change": "p.Ser868Phe",
                "transcript_id": "NM_024422.4",
                "dbsnp_id": "rs141873745",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI647"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1404/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1404/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1404/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1404/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "DSC2"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1404/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1405",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0006,
                    "KGP_genomes_AFR_maf": 0.0,
                    "KGP_genomes_AMR_maf": 0.0029,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.001,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.0005134,
                    "gnomad_AFR_maf": 0.0,
                    "gnomad_AMR_maf": 0.002027,
                    "gnomad_ASJ_maf": 0.0007943,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 9.243e-05,
                    "gnomad_NFE_maf": 0.0002817,
                    "gnomad_OTH_maf": 0.002445,
                    "gnomad_SAS_maf": 6.535e-05,
                    "ESP_AA_maf": null,
                    "ESP_EA_maf": null
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 2.000608,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 91670121,
                "genomic_position_hg38": 92040807,
                "chromosome": "7",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.922523",
                "ref_allele": "G",
                "alt_allele": "A",
                "cdna_change": "c.4826G>A",
                "protein_change": "p.Arg1609Lys",
                "transcript_id": "NM_005751.4",
                "dbsnp_id": "rs148146011",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI647"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1405/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1405/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1405/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1405/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "AKAP9"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1405/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1406",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.002,
                    "KGP_genomes_AFR_maf": 0.0,
                    "KGP_genomes_AMR_maf": 0.0058,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.006,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.005602,
                    "gnomad_AFR_maf": 0.001138,
                    "gnomad_AMR_maf": 0.006724,
                    "gnomad_ASJ_maf": 0.0179,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0009822,
                    "gnomad_NFE_maf": 0.007812,
                    "gnomad_OTH_maf": 0.009234,
                    "gnomad_SAS_maf": 0.0006587,
                    "ESP_AA_maf": 0.0,
                    "ESP_EA_maf": 0.01037
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 2.513736,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 112544125,
                "genomic_position_hg38": 110784367,
                "chromosome": "10",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.929394",
                "ref_allele": "C",
                "alt_allele": "T",
                "cdna_change": "c.1364C>T",
                "protein_change": "p.Ser455Leu",
                "transcript_id": "NM_001134363.2",
                "dbsnp_id": "rs189569984",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI647"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1406/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1406/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1406/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1406/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "RBM20"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1406/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1407",
            "attributes": {
                "frequencies": {
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                    "gnomad_ASJ_maf": null,
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                    "gnomad_OTH_maf": null,
                    "gnomad_SAS_maf": null,
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                },
                "predictions": {
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                    "mutationtaster_prediction": "Disease causing"
                },
                "status": "CU",
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                "chromosome": "4",
                "annotation_flag": "manually_attributed",
                "lastmodified": "2023-06-06T16:57:48.936170",
                "ref_allele": "C",
                "alt_allele": "T",
                "cdna_change": "c.331+1G>A",
                "protein_change": null,
                "transcript_id": "NM_001010874.5",
                "dbsnp_id": "rs1057517699",
                "variant_effect": "splicing"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
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                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI647"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1407/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1407/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1407/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1407/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "TECRL"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1407/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1408",
            "attributes": {
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                    "KGP_genomes_SAS_maf": null,
                    "gnomad_maf": 4.374e-05,
                    "gnomad_AFR_maf": 0.0,
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                    "gnomad_ASJ_maf": 0.0,
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                    "gnomad_NFE_maf": 8.79e-05,
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                },
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                    "pp2_hvar_prediction": "Damaging",
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                },
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                "genomic_position_hg19": 75863601,
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                "lastmodified": "2023-06-06T16:57:48.942860",
                "ref_allele": "A",
                "alt_allele": "T",
                "cdna_change": "c.2046A>T",
                "protein_change": "p.Leu682Phe",
                "transcript_id": "NM_014000.2",
                "dbsnp_id": "rs565398652",
                "variant_effect": "missense"
            },
            "relationships": {
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                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI647"
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                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1408/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1408/combinations/?format=api"
                    }
                },
                "gene_name": {
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                    },
                    "data": {
                        "type": "Gene",
                        "id": "VCL"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1408/?format=api"
            }
        }
    ],
    "meta": {
        "database_name": "OLIgogenic diseases DAtabase (OLIDA)",
        "resource_url": "olida.ibsquare.be",
        "api_release_year": "2021",
        "api_developer": [
            [
                "Arnau Dillen",
                "arnau.dillen@ulb.ac.be"
            ],
            [
                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
            ]
        ],
        "api_version": "0.3",
        "api_maintainers": [
            [
                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
            ]
        ],
        "api_documentation": [
            "olida.ibsquare.be/api/swagger",
            "olida.ibsquare.be/api/redoc"
        ],
        "copyright": "Copyright (c) 2026 · OLIDA All Rights Reserved.",
        "license": "CC Attribution-NonCommercial 4.0 International License",
        "ontologies": {
            "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO",
            "GENO": "http://purl.obolibrary.org/obo/geno.owl",
            "MI": "http://purl.obolibrary.org/obo/mi.owl",
            "NCIT": "http://purl.obolibrary.org/obo/ncit.owl",
            "OGI": "http://purl.obolibrary.org/obo/ogi.owl",
            "OGG": "http://purl.obolibrary.org/obo/ogg.owl"
        },
        "relevant_publications_doi": [
            "10.1093/nar/gkv1068",
            "10.1093/database/baac023"
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}