This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database

GET /api/combinations/OLI620/variants/?format=api
HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "SmallVariant",
            "id": "258",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0032,
                    "KGP_genomes_AFR_maf": 0.0008,
                    "KGP_genomes_AMR_maf": 0.0058,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.0109,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.006868,
                    "gnomad_AFR_maf": 0.001169,
                    "gnomad_AMR_maf": 0.007227,
                    "gnomad_ASJ_maf": 0.01082,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.003249,
                    "gnomad_NFE_maf": 0.01032,
                    "gnomad_OTH_maf": 0.008969,
                    "gnomad_SAS_maf": 0.001633,
                    "ESP_AA_maf": 0.0009099,
                    "ESP_EA_maf": 0.01024
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 2.588566,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 73002101,
                "genomic_position_hg38": 72709760,
                "chromosome": "15",
                "annotation_flag": "manually_corrected",
                "lastmodified": "2023-06-06T16:57:42.047857",
                "ref_allele": "A",
                "alt_allele": "G",
                "cdna_change": "c.137A>G",
                "protein_change": "p.Lys46Arg",
                "transcript_id": "NM_001320665.1",
                "dbsnp_id": "rs75295839",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 4
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI1116"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI1146"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI125"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI620"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/258/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/258/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/258/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/258/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "BBS4"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/258/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1361",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": null,
                    "KGP_genomes_AFR_maf": null,
                    "KGP_genomes_AMR_maf": null,
                    "KGP_genomes_EAS_maf": null,
                    "KGP_genomes_EUR_maf": null,
                    "KGP_genomes_SAS_maf": null,
                    "gnomad_maf": 3.981e-06,
                    "gnomad_AFR_maf": 6.152e-05,
                    "gnomad_AMR_maf": 0.0,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0,
                    "gnomad_NFE_maf": 0.0,
                    "gnomad_OTH_maf": 0.0,
                    "gnomad_SAS_maf": 0.0,
                    "ESP_AA_maf": null,
                    "ESP_EA_maf": null
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Possibly Damaging",
                    "cadd_prediction": 3.25974,
                    "mutationtaster_prediction": "Disease causing"
                },
                "status": "CU",
                "genomic_position_hg19": 122770055,
                "genomic_position_hg38": 121848900,
                "chromosome": "4",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.658160",
                "ref_allele": "T",
                "alt_allele": "G",
                "cdna_change": "c.878A>C",
                "protein_change": "p.Gln293Pro",
                "transcript_id": "NM_176824.2",
                "dbsnp_id": "rs889417696",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI620"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1361/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1361/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1361/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1361/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "BBS7"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1361/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1362",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0024,
                    "KGP_genomes_AFR_maf": 0.0008,
                    "KGP_genomes_AMR_maf": 0.0043,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.008,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.00549,
                    "gnomad_AFR_maf": 0.001823,
                    "gnomad_AMR_maf": 0.004898,
                    "gnomad_ASJ_maf": 0.0007967,
                    "gnomad_EAS_maf": 5.611e-05,
                    "gnomad_FIN_maf": 0.008172,
                    "gnomad_NFE_maf": 0.007883,
                    "gnomad_OTH_maf": 0.006552,
                    "gnomad_SAS_maf": 0.001728,
                    "ESP_AA_maf": 0.001604,
                    "ESP_EA_maf": 0.01107
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Damaging",
                    "cadd_prediction": 4.001116,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 27062666,
                "genomic_position_hg38": 27062668,
                "chromosome": "9",
                "annotation_flag": "manually_attributed",
                "lastmodified": "2023-06-06T16:57:48.663845",
                "ref_allele": "G",
                "alt_allele": "A",
                "cdna_change": "c.1735G>A",
                "protein_change": "p.Val579Met",
                "transcript_id": "NM_025103.2",
                "dbsnp_id": "rs138591335",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI620"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1362/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1362/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1362/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1362/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "IFT74"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1362/?format=api"
            }
        },
        {
            "type": "CopyNumberVariant",
            "id": "1363",
            "attributes": {
                "status": "CU",
                "genomic_position_hg19": 122749644,
                "genomic_position_hg38": 121828489,
                "chromosome": "4",
                "annotation_flag": "cnv",
                "lastmodified": "2021-10-18T11:01:08.259685",
                "location": "exon16_17",
                "sequence": "exon16_17",
                "number_of_repeats": null,
                "type_cnv": "deletion"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI620"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1363/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1363/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "data": {
                        "type": "Gene",
                        "id": "BBS7"
                    },
                    "links": {
                        "related": "https://olida.ibsquare.be/api/genes/BBS7/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1363/?format=api"
            }
        }
    ],
    "meta": {
        "database_name": "OLIgogenic diseases DAtabase (OLIDA)",
        "resource_url": "olida.ibsquare.be",
        "api_release_year": "2021",
        "api_developer": [
            [
                "Arnau Dillen",
                "arnau.dillen@ulb.ac.be"
            ],
            [
                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
            ]
        ],
        "api_version": "0.3",
        "api_maintainers": [
            [
                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
            ]
        ],
        "api_documentation": [
            "olida.ibsquare.be/api/swagger",
            "olida.ibsquare.be/api/redoc"
        ],
        "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.",
        "license": "CC Attribution-NonCommercial 4.0 International License",
        "ontologies": {
            "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO",
            "GENO": "http://purl.obolibrary.org/obo/geno.owl",
            "MI": "http://purl.obolibrary.org/obo/mi.owl",
            "NCIT": "http://purl.obolibrary.org/obo/ncit.owl",
            "OGI": "http://purl.obolibrary.org/obo/ogi.owl",
            "OGG": "http://purl.obolibrary.org/obo/ogg.owl"
        },
        "relevant_publications_doi": [
            "10.1093/nar/gkv1068",
            "10.1093/database/baac023"
        ],
        "Variant serializers": [
            "SmallVariantSerializer",
            "CopyNumberVariantSerializer"
        ],
        "size": 4
    }
}