This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database

GET /api/combinations/OLI601/variants/?format=api
HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "SmallVariant",
            "id": "1283",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0185,
                    "KGP_genomes_AFR_maf": 0.0688,
                    "KGP_genomes_AMR_maf": 0.0019,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.0,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.00541,
                    "gnomad_AFR_maf": 0.0656,
                    "gnomad_AMR_maf": 0.003613,
                    "gnomad_ASJ_maf": 0.0001347,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0,
                    "gnomad_NFE_maf": 0.0001505,
                    "gnomad_OTH_maf": 0.00177,
                    "gnomad_SAS_maf": 0.0001051,
                    "ESP_AA_maf": 0.05789,
                    "ESP_EA_maf": 0.0
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 0.154796,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 149638886,
                "genomic_position_hg38": 150470614,
                "chromosome": "X",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.207455",
                "ref_allele": "C",
                "alt_allele": "A",
                "cdna_change": "c.1041C>A",
                "protein_change": "p.His347Gln",
                "transcript_id": "NM_005491.4",
                "dbsnp_id": "NA",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI600"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI601"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1283/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1283/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1283/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1283/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "MAMLD1"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1283/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1288",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0052,
                    "KGP_genomes_AFR_maf": 0.0174,
                    "KGP_genomes_AMR_maf": 0.0029,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.001,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.002092,
                    "gnomad_AFR_maf": 0.01163,
                    "gnomad_AMR_maf": 0.001418,
                    "gnomad_ASJ_maf": 0.000199,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0007392,
                    "gnomad_NFE_maf": 0.002216,
                    "gnomad_OTH_maf": 0.002943,
                    "gnomad_SAS_maf": 0.0,
                    "ESP_AA_maf": 0.01226,
                    "ESP_EA_maf": 0.001395
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 2.095735,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 16436324,
                "genomic_position_hg38": 16436326,
                "chromosome": "9",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.238536",
                "ref_allele": "G",
                "alt_allele": "T",
                "cdna_change": "c.1868C>A",
                "protein_change": "p.Pro623His",
                "transcript_id": "NM_017637.5",
                "dbsnp_id": "rs114596065",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI601"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI602"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1288/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1288/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1288/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1288/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "BNC2"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1288/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1289",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0182,
                    "KGP_genomes_AFR_maf": 0.0681,
                    "KGP_genomes_AMR_maf": 0.0014,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.0,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.003639,
                    "gnomad_AFR_maf": 0.05186,
                    "gnomad_AMR_maf": 0.001976,
                    "gnomad_ASJ_maf": 0.0003016,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0,
                    "gnomad_NFE_maf": 0.000101,
                    "gnomad_OTH_maf": 0.002484,
                    "gnomad_SAS_maf": 3.288e-05,
                    "ESP_AA_maf": 0.04315,
                    "ESP_EA_maf": 0.0001168
                },
                "predictions": {
                    "sift_prediction": null,
                    "pp2_hvar_prediction": null,
                    "cadd_prediction": 1.841402,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 44388817,
                "genomic_position_hg38": 44388715,
                "chromosome": "5",
                "annotation_flag": "manually_attributed",
                "lastmodified": "2023-06-06T16:57:48.244866",
                "ref_allele": "C",
                "alt_allele": "T",
                "cdna_change": "c.-33G>A",
                "protein_change": null,
                "transcript_id": "NM_004465.2",
                "dbsnp_id": "rs17233910",
                "variant_effect": "unknown"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI601"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1289/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1289/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1289/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1289/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "FGF10"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1289/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1290",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0124,
                    "KGP_genomes_AFR_maf": 0.0439,
                    "KGP_genomes_AMR_maf": 0.0058,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.0,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.003038,
                    "gnomad_AFR_maf": 0.04187,
                    "gnomad_AMR_maf": 0.001128,
                    "gnomad_ASJ_maf": 0.0006951,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0,
                    "gnomad_NFE_maf": 0.0002908,
                    "gnomad_OTH_maf": 0.001473,
                    "gnomad_SAS_maf": 9.799e-05,
                    "ESP_AA_maf": 0.04244,
                    "ESP_EA_maf": 0.0001163
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 0.986069,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 119964831,
                "genomic_position_hg38": 119422208,
                "chromosome": "1",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.251160",
                "ref_allele": "T",
                "alt_allele": "C",
                "cdna_change": "c.707T>C",
                "protein_change": "p.Leu236Ser",
                "transcript_id": "NM_000198.3",
                "dbsnp_id": "rs35887327",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI601"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1290/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1290/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1290/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1290/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "HSD3B2"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1290/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1291",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0184,
                    "KGP_genomes_AFR_maf": 0.0613,
                    "KGP_genomes_AMR_maf": 0.0058,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.006,
                    "KGP_genomes_SAS_maf": 0.001,
                    "gnomad_maf": 0.007434,
                    "gnomad_AFR_maf": 0.05435,
                    "gnomad_AMR_maf": 0.008408,
                    "gnomad_ASJ_maf": 0.004863,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0008233,
                    "gnomad_NFE_maf": 0.005185,
                    "gnomad_OTH_maf": 0.008159,
                    "gnomad_SAS_maf": 0.00115,
                    "ESP_AA_maf": 0.04372,
                    "ESP_EA_maf": 0.00421
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 1.867149,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 54967040,
                "genomic_position_hg38": 54933128,
                "chromosome": "16",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.257329",
                "ref_allele": "C",
                "alt_allele": "T",
                "cdna_change": "c.707C>T",
                "protein_change": "p.Pro236Leu",
                "transcript_id": "NM_005853.5",
                "dbsnp_id": "rs115549200",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI601"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1291/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1291/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1291/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1291/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "IRX5"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1291/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1292",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.0142,
                    "KGP_genomes_AFR_maf": 0.0507,
                    "KGP_genomes_AMR_maf": 0.0058,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.0,
                    "KGP_genomes_SAS_maf": 0.0,
                    "gnomad_maf": 0.003583,
                    "gnomad_AFR_maf": 0.051,
                    "gnomad_AMR_maf": 0.002028,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 4.643e-05,
                    "gnomad_NFE_maf": 0.0001507,
                    "gnomad_OTH_maf": 0.001655,
                    "gnomad_SAS_maf": 0.0001634,
                    "ESP_AA_maf": 0.05031,
                    "ESP_EA_maf": 0.0002416
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Damaging",
                    "cadd_prediction": 3.925982,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 95826473,
                "genomic_position_hg38": 96093309,
                "chromosome": "11",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.263528",
                "ref_allele": "C",
                "alt_allele": "T",
                "cdna_change": "c.722G>A",
                "protein_change": "p.Arg241Gln",
                "transcript_id": "NM_032427.3",
                "dbsnp_id": "rs111958464",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI601"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1292/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1292/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1292/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1292/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "MAML2"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1292/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "1293",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": 0.011,
                    "KGP_genomes_AFR_maf": 0.0,
                    "KGP_genomes_AMR_maf": 0.0029,
                    "KGP_genomes_EAS_maf": 0.0,
                    "KGP_genomes_EUR_maf": 0.008,
                    "KGP_genomes_SAS_maf": 0.046,
                    "gnomad_maf": 0.01105,
                    "gnomad_AFR_maf": 0.001423,
                    "gnomad_AMR_maf": 0.004159,
                    "gnomad_ASJ_maf": 0.005131,
                    "gnomad_EAS_maf": 0.0001647,
                    "gnomad_FIN_maf": 0.002344,
                    "gnomad_NFE_maf": 0.007631,
                    "gnomad_OTH_maf": 0.01289,
                    "gnomad_SAS_maf": 0.05166,
                    "ESP_AA_maf": 0.001135,
                    "ESP_EA_maf": 0.006977
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 2.50846,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 120469147,
                "genomic_position_hg38": 119926524,
                "chromosome": "1",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:48.269839",
                "ref_allele": "T",
                "alt_allele": "C",
                "cdna_change": "c.3980A>G",
                "protein_change": "p.Asp1327Gly",
                "transcript_id": "NM_024408.3",
                "dbsnp_id": "rs61752484",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI601"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1293/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1293/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/1293/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/1293/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "NOTCH2"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/1293/?format=api"
            }
        }
    ],
    "meta": {
        "database_name": "OLIgogenic diseases DAtabase (OLIDA)",
        "resource_url": "olida.ibsquare.be",
        "api_release_year": "2021",
        "api_developer": [
            [
                "Arnau Dillen",
                "arnau.dillen@ulb.ac.be"
            ],
            [
                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
            ]
        ],
        "api_version": "0.3",
        "api_maintainers": [
            [
                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
            ]
        ],
        "api_documentation": [
            "olida.ibsquare.be/api/swagger",
            "olida.ibsquare.be/api/redoc"
        ],
        "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.",
        "license": "CC Attribution-NonCommercial 4.0 International License",
        "ontologies": {
            "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO",
            "GENO": "http://purl.obolibrary.org/obo/geno.owl",
            "MI": "http://purl.obolibrary.org/obo/mi.owl",
            "NCIT": "http://purl.obolibrary.org/obo/ncit.owl",
            "OGI": "http://purl.obolibrary.org/obo/ogi.owl",
            "OGG": "http://purl.obolibrary.org/obo/ogg.owl"
        },
        "relevant_publications_doi": [
            "10.1093/nar/gkv1068",
            "10.1093/database/baac023"
        ],
        "Variant serializers": [
            "SmallVariantSerializer",
            "CopyNumberVariantSerializer"
        ],
        "size": 7
    }
}