This API endpoint handles listing (/variants) and retrieval (/variants/<ID>/) of genetic variants from the database

GET /api/combinations/OLI331/variants/?format=api
HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "SmallVariant",
            "id": "638",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": null,
                    "KGP_genomes_AFR_maf": null,
                    "KGP_genomes_AMR_maf": null,
                    "KGP_genomes_EAS_maf": null,
                    "KGP_genomes_EUR_maf": null,
                    "KGP_genomes_SAS_maf": null,
                    "gnomad_maf": 1.193e-05,
                    "gnomad_AFR_maf": 0.0,
                    "gnomad_AMR_maf": 0.0,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 4.619e-05,
                    "gnomad_NFE_maf": 1.758e-05,
                    "gnomad_OTH_maf": 0.0,
                    "gnomad_SAS_maf": 0.0,
                    "ESP_AA_maf": null,
                    "ESP_EA_maf": null
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Possibly Damaging",
                    "cadd_prediction": 3.0021,
                    "mutationtaster_prediction": "Disease causing"
                },
                "status": "CU",
                "genomic_position_hg19": 33039600,
                "genomic_position_hg38": 31667287,
                "chromosome": "21",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:44.253400",
                "ref_allele": "C",
                "alt_allele": "T",
                "cdna_change": null,
                "protein_change": "p.Ala90Val",
                "transcript_id": null,
                "dbsnp_id": "rs1280042397",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 8
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI328"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI329"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI330"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI331"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI332"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI333"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI334"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI335"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/638/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/638/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/638/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/638/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "SOD1"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/638/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "666",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": null,
                    "KGP_genomes_AFR_maf": null,
                    "KGP_genomes_AMR_maf": null,
                    "KGP_genomes_EAS_maf": null,
                    "KGP_genomes_EUR_maf": null,
                    "KGP_genomes_SAS_maf": null,
                    "gnomad_maf": 3.976e-06,
                    "gnomad_AFR_maf": 0.0,
                    "gnomad_AMR_maf": 0.0,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0,
                    "gnomad_NFE_maf": 8.791e-06,
                    "gnomad_OTH_maf": 0.0,
                    "gnomad_SAS_maf": 0.0,
                    "ESP_AA_maf": null,
                    "ESP_EA_maf": null
                },
                "predictions": {
                    "sift_prediction": "Deleterious",
                    "pp2_hvar_prediction": "Possibly Damaging",
                    "cadd_prediction": 2.735101,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 1817362,
                "genomic_position_hg38": 1869196,
                "chromosome": "8",
                "annotation_flag": "automatically_attributed_and_verified",
                "lastmodified": "2023-06-06T16:57:44.440191",
                "ref_allele": "C",
                "alt_allele": "A",
                "cdna_change": "c.700C>A",
                "protein_change": "p.Pro234Thr",
                "transcript_id": "NM_001308153.2",
                "dbsnp_id": "rs545402502",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI331"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/666/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/666/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/666/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/666/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "ARHGEF10"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/666/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "667",
            "attributes": {
                "frequencies": {
                    "KGP_genomes_maf": null,
                    "KGP_genomes_AFR_maf": null,
                    "KGP_genomes_AMR_maf": null,
                    "KGP_genomes_EAS_maf": null,
                    "KGP_genomes_EUR_maf": null,
                    "KGP_genomes_SAS_maf": null,
                    "gnomad_maf": 0.0004188,
                    "gnomad_AFR_maf": 0.0001846,
                    "gnomad_AMR_maf": 0.0,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 0.0003698,
                    "gnomad_NFE_maf": 0.0008219,
                    "gnomad_OTH_maf": 0.0,
                    "gnomad_SAS_maf": 3.266e-05,
                    "ESP_AA_maf": 0.0004539,
                    "ESP_EA_maf": 0.001047
                },
                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 1.408532,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 22985294,
                "genomic_position_hg38": 22945675,
                "chromosome": "7",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:44.446753",
                "ref_allele": "C",
                "alt_allele": "T",
                "cdna_change": "c.1480G>A",
                "protein_change": "p.Val494Ile",
                "transcript_id": "NM_032581.3",
                "dbsnp_id": "rs151228394",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
                    "meta": {
                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI331"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/667/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/667/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/667/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/667/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "FAM126A"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/667/?format=api"
            }
        },
        {
            "type": "SmallVariant",
            "id": "668",
            "attributes": {
                "frequencies": {
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                    "KGP_genomes_AFR_maf": null,
                    "KGP_genomes_AMR_maf": null,
                    "KGP_genomes_EAS_maf": null,
                    "KGP_genomes_EUR_maf": null,
                    "KGP_genomes_SAS_maf": null,
                    "gnomad_maf": 0.0001051,
                    "gnomad_AFR_maf": 0.0,
                    "gnomad_AMR_maf": 5.799e-05,
                    "gnomad_ASJ_maf": 0.0,
                    "gnomad_EAS_maf": 0.0,
                    "gnomad_FIN_maf": 4.792e-05,
                    "gnomad_NFE_maf": 0.0001978,
                    "gnomad_OTH_maf": 0.0001649,
                    "gnomad_SAS_maf": 0.0,
                    "ESP_AA_maf": 0.0,
                    "ESP_EA_maf": 0.0003489
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                "predictions": {
                    "sift_prediction": "Tolerated",
                    "pp2_hvar_prediction": "Benign",
                    "cadd_prediction": 2.185433,
                    "mutationtaster_prediction": "Polymorphism"
                },
                "status": "CU",
                "genomic_position_hg19": 48956113,
                "genomic_position_hg38": 48452856,
                "chromosome": "19",
                "annotation_flag": "automatically_attributed",
                "lastmodified": "2023-06-06T16:57:44.453410",
                "ref_allele": "C",
                "alt_allele": "T",
                "cdna_change": "c.1172C>T",
                "protein_change": "p.Ala391Val",
                "transcript_id": "NM_031485.3",
                "dbsnp_id": "rs377325041",
                "variant_effect": "missense"
            },
            "relationships": {
                "in_combination": {
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                        "count": 1
                    },
                    "data": [
                        {
                            "type": "Combination",
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                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/668/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/668/combinations/?format=api"
                    }
                },
                "gene_name": {
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/668/relationships/gene_name?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/668/gene/?format=api"
                    },
                    "data": {
                        "type": "Gene",
                        "id": "GRWD1"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/variants/668/?format=api"
            }
        },
        {
            "type": "SmallVariant",
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                "ref_allele": "C",
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                "cdna_change": "c.214C>T",
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            },
            "relationships": {
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                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/variants/669/relationships/in_combination?format=api",
                        "related": "https://olida.ibsquare.be/api/variants/669/combinations/?format=api"
                    }
                },
                "gene_name": {
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                        "self": "https://olida.ibsquare.be/api/variants/669/relationships/gene_name?format=api",
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                    },
                    "data": {
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                }
            },
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                "self": "https://olida.ibsquare.be/api/variants/669/?format=api"
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        },
        {
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                "ref_allele": "A",
                "alt_allele": "G",
                "cdna_change": "c.3416A>G",
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                },
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                }
            },
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                "self": "https://olida.ibsquare.be/api/variants/672/?format=api"
            }
        }
    ],
    "meta": {
        "database_name": "OLIgogenic diseases DAtabase (OLIDA)",
        "resource_url": "olida.ibsquare.be",
        "api_release_year": "2021",
        "api_developer": [
            [
                "Arnau Dillen",
                "arnau.dillen@ulb.ac.be"
            ],
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                "Charlotte Nachtegael",
                "charlotte.nachtegael@ulb.be"
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        "api_version": "0.3",
        "api_maintainers": [
            [
                "Charlotte Nachtegael",
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        "api_documentation": [
            "olida.ibsquare.be/api/swagger",
            "olida.ibsquare.be/api/redoc"
        ],
        "copyright": "Copyright (c) 2026 · OLIDA All Rights Reserved.",
        "license": "CC Attribution-NonCommercial 4.0 International License",
        "ontologies": {
            "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO",
            "GENO": "http://purl.obolibrary.org/obo/geno.owl",
            "MI": "http://purl.obolibrary.org/obo/mi.owl",
            "NCIT": "http://purl.obolibrary.org/obo/ncit.owl",
            "OGI": "http://purl.obolibrary.org/obo/ogi.owl",
            "OGG": "http://purl.obolibrary.org/obo/ogg.owl"
        },
        "relevant_publications_doi": [
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            "10.1093/database/baac023"
        ],
        "Variant serializers": [
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            "CopyNumberVariantSerializer"
        ],
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    }
}