Gene Combination List – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/combinations/OLI307/genecombinations/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": [
        {
            "type": "GeneCombination",
            "id": "204",
            "attributes": {
                "gene_relationship": [
                    "Relevant pathways for phenotype",
                    "Same pathway",
                    "Affecting the same tissue"
                ],
                "protein_interactions": [],
                "common_pathways": [
                    "Signaling by WNT in cancer",
                    "Regulation of FZD by ubiquitination",
                    "Gastric cancer",
                    "mTOR signaling pathway",
                    "Breast cancer",
                    "Disease",
                    "Pathways of neurodegeneration - multiple diseases",
                    "Pathways in cancer",
                    "Alzheimer disease",
                    "Hepatocellular carcinoma",
                    "Signaling by RNF43 mutants",
                    "Wnt signaling pathway",
                    "Signaling by WNT",
                    "Signal Transduction",
                    "TCF dependent signaling in response to WNT",
                    "Diseases of signal transduction by growth factor receptors and second messengers"
                ],
                "genecomb_metascore": 2,
                "lastmodified": "2024-03-01T15:02:30.424647"
            },
            "relationships": {
                "combination_set": {
                    "meta": {
                        "count": 11
                    },
                    "data": [
                        {
                            "type": "Combination",
                            "id": "OLI303"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI304"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI305"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI306"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI307"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI308"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI309"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI419"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI1252"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI1253"
                        },
                        {
                            "type": "Combination",
                            "id": "OLI1257"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/204/relationships/combination_set?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/204/combinations/?format=api"
                    }
                },
                "genes": {
                    "meta": {
                        "count": 2
                    },
                    "data": [
                        {
                            "type": "Gene",
                            "id": "FZD4"
                        },
                        {
                            "type": "Gene",
                            "id": "LRP5"
                        }
                    ],
                    "links": {
                        "self": "https://olida.ibsquare.be/api/genecombinations/204/relationships/genes?format=api",
                        "related": "https://olida.ibsquare.be/api/genecombinations/204/genes/?format=api"
                    }
                }
            },
            "links": {
                "self": "https://olida.ibsquare.be/api/genecombinations/204/?format=api"
            }
        }
    ]
}